Ben Fabry
Prof. Dr. Ben Fabry
Head
Biophysics Group
- Phone number: +49 9131 85-25610
- Email: ben.fabry@fau.de
- Website: https://bio.physik.fau.de
Our laboratory studies the mechanical behavior of cells, including cell adhesion, spreading, deformation, motion, migration, invasion, stiffness, viscosity, force generation and mechano-transduction. These mechanical processes are essential for many cellular functions. Abnormal cell mechanical behavior is often associated with severe disorders such as cancer or cardiovascular diseases. We collaborate with research groups worldwide to develop novel technologies that enable us to measure or apply small forces (in the pico-Newton range) and deformations (in the low nano-meter range) that are relevant for cell mechanical functions. We use these technologies to study the behavior of cells on nano-structured biomaterials, cancer cell migration in 3-dimensional biopolymer networks, or the biochemistry of adhesion proteins.
Ben Fabry studied Electrical Engineering at the Technical University of Dresden, Germany. In 1991 he joined the R&D group of the Anesthesiology and Intensive Care Medicine division at Draegerwerk AG, Luebeck, Germany, and subsequently the Department of Clinical Physiology at the University of Basel, Switzerland. After receiving his doctorate degree in Electrical Engineering in 1995, he was a research assistant, and after 1999 a research associate at the Physiology Program, Harvard School of Public Health, Boston, MA, where he worked on smooth muscle physiology and cellular biomechanics. Since 2003, Ben Fabry has been Professor for Medical Physics and Technology at the University of Erlangen-Nuremberg, Germany, and since 2005 he has been the administrative head of the Center for Medical Physics and Technology at the University.
2026
2026
- Continuous monitoring of endotracheal tube obstructions using naturally occurring pressure and flow oscillations
In medRxiv, 2026. - Resistive Load During CPAP and Automatic Tube Compensation (ATC): A Bench Comparison of ICU Ventilators
In medRxiv, 2026. - Semi-automated identification of southern right whales from drone imagery by classical image matching methods
In bioRxiv, 2026. - Ventilator and method for controlling a ventilator
US Patent App. 19/106,065, 2026, 2026. - Immune cells employ intermittent integrin-mediated traction forces for 3D migration
In Proceedings of the National Academy of Sciences, volume 123, number 11, pp. e2524427123, 2026. - Compression‐Tension‐Asymmetry and Stiffness Nonlinearity of Collagen‐Matrigel Composite Hydrogels
In Advanced Healthcare Materials, volume 15, number 9, pp. e03052, 2026. - Advanced Characterization of Plastron on Cassie–Baxter Superhydrophobic Surfaces by Drop Adhesion Force
In Langmuir, volume 42, number 12, pp. 8280–8289, 2026.
2025
2025
- Differences in ventilatory muscle recruitment and work of breathing in COPD and interstitial lung disease
ERJ open research 11 (2), 00881-2024, 2025, 2025. - The influence of different immunosuppressive drugs on ex vivo expanded regulatory T cells
EXPERIMENTAL DERMATOLOGY 34 (3), 2025, 2025. - 1030: PIEZO CHANNELS WITHIN INTESTINAL EPITHELIUM: GUARDIANS OF COLORECTAL CANCER?
Gastroenterology 169 (1), S-248, 2025, 2025. - PIEZO CHANNELS WITHIN INTESTINAL EPITHELIUM: GUARDIANS OF COLORECTAL CANCER?
GASTROENTEROLOGY 139 (1), 2025, 2025. - Contractility of striated muscle tissue increases with environmental stiffness according to a power-law relationship
In npj Biological Physics and Mechanics, volume 2, number 1, pp. 7, 2025. - Prediction and prevention of ventilation impairments during bronchoscopy
In Intensive Care Medicine Experimental, volume 13, number 1, pp. 130, 2025.
2024
2024
- Remote sensing of emperor penguin abundance and breeding success
In Nature Communications, volume 15, number 1, pp. 4419, 2024. - Predicting plastron thermodynamic stability for underwater superhydrophobicity
In Communications Materials, volume 5, number 1, pp. 112, 2024. - Cancer cell migration depends on adjacent ASC and adipose spheroids in a 3D bioprinted breast cancer model
In Biofabrication, volume 16, number 3, pp. 035031, 2024. - Dynamic traction force measurements of migrating immune cells in 3D biopolymer matrices
In Nature Physics, 2024. - How to minimize mechanical power during controlled mechanical ventilation
In Intensive Care Medicine Experimental, volume 12, number 114, 2024.
2023
2023
- Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility
In Matrix Biol, volume 124, pp. 39–48, 2023. - Clinorotation inhibits myotube formation by fluid motion, not by simulated microgravity
European Journal of Cell Biology 102 (2), 151330, 2023, 2023. - Simulated microgravity during clino-rotation is disturbed by spurious fluid motion
In bioRxiv, pp. 2023.02.10.527979, 2023. - Predicting cell stress and strain during extrusion bioprinting
Physical Review Applied 19 (6), 064061, 2023, 2023. - Silicone-Based Lubricant-Infused Slippery Coating Covalently Bound to Aluminum Substrates for Underwater Applications
In ACS Applied Materials & Interfaces, 2023. - Directionality of developing skeletal muscles is set by mechanical forces
In Nature Communications, volume 14, number 1, pp. 3060, 2023. - Long-term stability of aerophilic metallic surfaces underwater
In Nat Mater, 2023.
2022
2022
- Calcium supplementation of bioinks reduces shear stress-induced cell damage during bioprinting
In Biofabrication, volume 14, number 4, pp. 045005, 2022. - Viscoelastic properties of suspended cells measured with shear flow deformation cytometry
In eLife, volume 11, pp. e78823, 2022. - Biologging of emperor penguins-Attachment techniques and associated deployment performance
In PLoS One, volume 17, number 8, pp. e0265849, 2022. - Juvenile emperor penguin range calls for extended conservation measures in the Southern Ocean
In R Soc Open Sci, volume 9, number 8, pp. 211708, 2022. - Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation
In Gut, 2022. - Plectin-mediated cytoskeletal crosstalk controls cell tension and cohesion in epithelial sheets
In J Cell Biol, volume 221, number 3, 2022. - Dual-wavelength stopped-flow analysis of the lateral and longitudinal assembly kinetics of vimentin
In Biophysical Journal, volume 121, number 20, pp. 3850–3861, 2022. - The desmin mutation R349P increases contractility and fragility of stem cell-generated muscle micro-tissues
In Neuropathology and Applied Neurobiology, volume 48, number 3, pp. e12784, 2022. - The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load
In Current Biology, 2022.
2021
2021
- pyTFM: A tool for traction force and monolayer stress microscopy
In PLOS Computational Biology, volume 17, number 6, pp. e1008364, 2021. - Fast phenotyping of monocytes mechanics under the cytokine storm
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 50 (SUPPL 1), 133-133, 2021, 2021. - Stress relaxation amplitude of hydrogels determines migration, proliferation, and morphology of cells in 3-D culture
In Biomaterials Science, 2021. - Bioprinting and Differentiation of Adipose-Derived Stromal Cell Spheroids for a 3D Breast Cancer-Adipose Tissue Model
In Cells, volume 10, number 4, 2021. - An Interactive Framework for Teaching Viscoelastic Modeling
In The Biophysicist, volume 2, number 3, pp. 18–28, 2021. - A low-cost uniaxial cell stretcher for six parallel wells
In HardwareX, volume 9, pp. e00162, 2021. - Plectin ensures intestinal epithelial integrity and protects colon against colitis
In Mucosal Immunology, volume 14, number 3, pp. 691–702, 2021. - Detecting long-range interactions between migrating cells
In Scientific Reports, volume 11, number 1, pp. 15031, 2021.
2020
2020
- High-Force Magnetic Tweezers with Hysteresis-Free Force Feedback
In Biophysical Journal, volume 119, number 1, pp. 15–23, 2020. - Collective forces of tumor spheroids in three-dimensional biopolymer networks
In eLife, volume 9, pp. e51912, 2020. - Cryopreservation impairs 3-D migration and cytotoxicity of natural killer cells
In Nature Communications, volume 11, number 1, pp. 5224, 2020. - Flow and hydrodynamic shear stress inside a printing needle during biofabrication
In PLoS One, volume 15, number 7, pp. e0236371, 2020. - Measurement of Skeletal Muscle Fiber Contractility with High-Speed Traction Microscopy
In Biophys J, volume 118, number 3, pp. 657–666, 2020. - Durotropic Growth of Pollen Tubes
In Plant Physiology, volume 183, number 2, pp. 558, 2020. - micrObs – A customizable time-lapse camera for ecological studies
In HardwareX, volume 8, pp. e00134, 2020.
2019
2019
- Breast cancer cells adapt contractile forces to overcome steric hindrance
In Biophysical Journal, volume 116, pp. 1305–1312, 2019. - CameraTransform: A Python package for perspective corrections and image mapping
In SoftwareX, volume 10, pp. 100333, 2019. - Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery
In Sci Rep, volume 9, number 1, pp. 13439, 2019. - Intracellular Drug Delivery with Anodic Titanium Dioxide Nanotubes and Nanocylinders
In ACS Appl Mater Interfaces, volume 11, number 16, pp. 14980–14985, 2019. - Imaging localized neuronal activity at fast time scales through biomechanics
In Science Advances, volume 5, number 4, pp. –, 2019. - Treatment of keratinocytes with 4-phenylbutyrate in epidermolysis bullosa: Lessons for therapies in keratin disorders
In EBioMedicine, volume 44, pp. 502–515, 2019.
2018
2018
- Vinculin regulates lamellipodium protrusion velocity.
MOLECULAR BIOLOGY OF THE CELL 29 (26), 2018, 2018. - Structural organisation and dynamics in king penguin colonies
In Journal of Physics D: Applied Physics, volume 51, number 16, pp. 164004, 2018. - Plectin stabilizes hemidesmosomes and protect colon from colitis.
MOLECULAR BIOLOGY OF THE CELL 29 (26), 2018, 2018. - Bayesian model selection for complex dynamic systems
In Nat Commun, volume 9, number 1, pp. 1803, 2018. - Pressure-driven collective growth mechanism of planar cell colonies
In Journal of Physics D-Applied Physics, volume 51, number 30, 2018. - Phase transitions in huddling emperor penguins
In Journal of Physics D-Applied Physics, volume 51, number 21, 2018. - A remote‐controlled observatory for behavioural and ecological research: A case study on emperor penguins
In Methods in Ecology and Evolution, volume 0, number 0, 2018. - NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover
In J Bone Miner Res, volume 33, number 11, pp. 2035–2047, 2018. - β-parvin orchestrates the induction of physiological cardiac hypertrophy.
Molecular Biology Of The Cell 29 (26), 2018, 2018.
2017
2017
- The focal adhesion targeting domain of p130Cas confers a mechanosensing function
In J Cell Sci, volume 130, number 7, pp. 1263–1273, 2017. - The role of focal adhesion anchoring domains of CAS in mechanotransduction
In Sci Rep, volume 7, pp. 46233, 2017. - Traction Force Microscopy in 3-Dimensional Extracellular Matrix Networks
In Curr Protoc Cell Biol, volume 75, pp. 10 22 1–10 22 20, 2017. - Early signs of architectural and biomechanical failure in isolated myofibers and immortalized myoblasts from desmin-mutant knock-in mice
In Sci Rep, volume 7, number 1, pp. 1391, 2017. - Forces and cytoskeletal dynamics during collective invasion of tumor spheroids
MOLECULAR BIOLOGY OF THE CELL 28, 2017, 2017. - Adaptive stochastic resonance for unknown and variable input signals
In Sci Rep, volume 7, number 1, pp. 2450, 2017. - Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions
In Biophys J, volume 112, number 7, pp. 1472–1480, 2017. - Fluctuations in directional persistence and cell speed define cell migration strategies.
MOLECULAR BIOLOGY OF THE CELL 28, 2017, 2017.
2016
2016
- Mechanical plasticity of cells
In Nat Mater, volume 15, number 10, pp. 1090–4, 2016. - ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
In Nat Commun, volume 7, pp. 12630, 2016. - Examining Spatio-Temporal Dynamics of Cell-Substrate Linkers during Cell Migration using Polymer-Tethered Lipid Multi-Bilayers of Adjustable Stiffness
Biophysical Journal 110 (3), 132a-133a, 2016, 2016. - N-cadherin-functionalized polymer-tethered multi-bilayer: a cell surface-mimicking substrate to probe cellular mechanosensitivity
In Soft Matter, volume 12, number 40, pp. 8274–8284, 2016. - ClickPoints: an expandable toolbox for scientific image annotation and analysis
In Methods in Ecology and Evolution, 2016. - Differential response of patient-derived primary glioblastoma cells to environmental stiffness
In Sci Rep, volume 6, pp. 23353, 2016. - Cell Mechanical Properties Measured with Micron-Scale Constrictions: Influence of Pressure, Strain and Culture Conditions
Biophysical Journal 110 (3), 135a, 2016, 2016. - The Role of Heterogeneity in Cancer Cell Migration
Biophysical Journal 110 (3), 621a, 2016, 2016. - The IsoStretcher: An isotropic cell stretch device to study mechanical biosensor pathways in living cells
In Biosens Bioelectron, volume 81, pp. 363–72, 2016. - Three-dimensional force microscopy of cells in biopolymer networks
In Nat Methods, volume 13, number 2, pp. 171–6, 2016. - Cell Adhesion on Surface-Functionalized Magnesium
In ACS Appl Mater Interfaces, volume 8, number 19, pp. 11998–2006, 2016.
2015
2015
- Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission
In J Cell Sci, volume 128, number 18, pp. 3435–43, 2015. - Determining the mechanical properties of plectin in mouse myoblasts and keratinocytes
In Exp Cell Res, pp. 331–337, 2015. - Activation and regulation of endogenous retroviral genes in the human pituitary gland and related endocrine tumours
In Neuropathol Appl Neurobiol, volume 41, number 2, pp. 180–200, 2015. - Emergence of Asynchronous Local Clocks in Excitable Media
In PLoS One, volume 10, number 11, pp. e0142490, 2015. - Imaging viscoelastic properties of living cells by AFM: Power-law rheology on the nanoscale
In Soft Matter, volume 11, pp. 4553–4732, 2015. - Biphasic response of cell invasion to matrix stiffness in three-dimensional biopolymer networks
In Acta Biomater, volume 13, pp. 61–7, 2015. - Microconstriction Arrays for High-Throughput Quantitative Measurements of Cell Mechanical Properties
In Biophys J, volume 109, number 1, pp. 26–34, 2015. - Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness
In Biophys J, volume 109, number 5, pp. 900–13, 2015. - Stress controls the mechanics of collagen networks
In Proc Natl Acad Sci U S A, volume 112, number 31, pp. 9573–8, 2015. - Superstatistical analysis and modelling of heterogeneous random walks
In Nat Comm, volume 6, pp. 7516, 2015. - Probing cellular mechano-sensitivity using biomembrane-mimicking cell substrates of adjustable stiffness
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 249, 2015, 2015. - Mechanotransduction: use the force(s)
In BMC Biol, volume 13, pp. 47, 2015. - Alginate-based hydrogels with improved adhesive properties for cell encapsulation
In Int J Biol Macromol, volume 78, pp. 72–8, 2015. - Imaging viscoelastic properties of live cancer cells with atomic force microscopy
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 44, S82-S82, 2015, 2015. - Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen
In FASEB J, volume 29, number 11, pp. 4555–67, 2015. - Vinculin F-actin interaction regulates lamellipodium protrusion velocity
MOLECULAR BIOLOGY OF THE CELL 26, 2015, 2015. - In-Vivo Imaging of Cell Migration Using Contrast Enhanced MRI and SVM Based Post-Processing
In PLoS One, volume 10, number 12, pp. e0140548, 2015.
2014
2014
- Tumor cell migration is a superstatistical process
APS March Meeting Abstracts 2014, Q40. 005, 2014, 2014. - Behavior of Encapsulated MG-63 Cells in RGD and Gelatine-Modified Alginate Hydrogels
In Tissue Eng Part A, 2014. - CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics
In Cell Mol Life Sci, volume 71, number 4, pp. 727–744, 2014. - Nuclear deformability is critically dependent on lamin A/B
Biophysical Journal 106 (2), 576a, 2014, 2014. - Biomembrane-mimicking lipid bilayer system as a mechanically tunable cell substrate
In Biomaterials, volume 35, number 10, pp. 3198–207, 2014. - Bayesian inference of time varying parameters in autoregressive processes
In arXiv:1405.1668, 2014. - Changes in cell-cell contacts of endothelial cells (HUVEC) under long term shear stress conditions
Angiogenesis 17 (4), 962-962, 2014, 2014. - Fibrous protein-based hydrogels for cell encapsulation
In Biomaterials, volume 35, number 25, pp. 6727–6738, 2014. - Migration, Force Generation and Mechanosensing of Cells in Collagen Gels
Biophysical Journal 106 (2), 425a, 2014, 2014. - Are environmental factors responsible for changed breeding behaviour in emperor penguins?
In Antarctic Science, 2014.
2013
2013
- Quantifying cell-to-cell variation in power-law rheology
In Biophys J, volume 105, number 5, pp. 1093–102, 2013. - The origin of traveling waves in an emperor penguin huddle
In News J Phys, volume 35, 2013. - Vinculin, cell mechanics and tumour cell invasion
In Cell Biol Int, volume 37, number 5, pp. 397–405, 2013. - Identification of DAPK as a scaffold protein for the LIMK/cofilin complex in TNF-induced apoptosis
In Int J Biochem Cell Biol, volume 45, number 8, pp. 1720–9, 2013. - Acquisition of paclitaxel resistance is associated with a more aggressive and invasive phenotype in prostate cancer
In J Cell Biochem, volume 114, number 6, pp. 1286–93, 2013. - Effects of matrix stiffness and steric hindrance on cell migration in 3D
MOLECULAR BIOLOGY OF THE CELL 24, 2013, 2013. - Estimating the 3D pore size distribution of biopolymer networks from directionally biased data
In Biophys J, volume 105, pp. 1967–1975, 2013. - Cell and tissue mechanics in cell migration
In Exp Cell Res, volume 319, number 16, pp. 2418–23, 2013. - Differences in mesenchymal and epithelial cell colony growth
MOLECULAR BIOLOGY OF THE CELL 24, 2013, 2013. - Mechanosensing of Cells in Laminin-Fuctionalized Biomembrane-Mimicking Substrates
In Biophysical Journal, volume 104, number 2, Supplement 1, pp. 319a, 2013. - Migration through narrow channels: How cancer cells evade the steric hindrance of a 3D matrix.
MOLECULAR BIOLOGY OF THE CELL 24, 2013, 2013. - Mechanosensitivity of myoblasts, fibroblasts, and PC-12 cells on biomembrane-mimicking substrates with tunable viscoelasticity
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 246, 2013, 2013. - A simplified implementation of the bubble analysis of biopolymer network pores
In Biophys J, volume 104, number 12, pp. 2774–5, 2013. - Strain history dependence of the nonlinear stress response of fibrin and collagen networks
In Proc Natl Acad Sci U S A, volume 110, number 30, pp. 12197–202, 2013. - Structure and mechanics of fibrin clots formed under mechanical perturbation
In J Thromb Haemost, volume 11, number 3, pp. 557–60, 2013. - Mechanics and Structure of Fibrin Networks Polymerized under Oscillatory Shear Perturbations
Biophysical Journal 104 (2), 142a, 2013, 2013. - Labeling of cancer cells with magnetic nanoparticles for magnetic resonance imaging
In Magn Reson Med, 2013.
2012
2012
- Biomechanical characterization of a desminopathy in primary human myoblasts
In Biochem Biophys Res Commun, volume 419, number 4, pp. 703–7, 2012. - Direct Observation of Catch-Bonds in Focal Adhesions of Living Cells
Biophysical Journal 102 (3), 12a, 2012, 2012. - Occupy tissue: the movement in cancer metastasis
In Cell Adh Migr, volume 6, number 5, pp. 424–32, 2012. - Inhibition of Rho kinases increases directional motility of microvascular endothelial cells
In Biochem Pharmacol, volume 83, number 5, pp. 616–26, 2012. - Swarm model for the huddling behavior of Emperor penguins
2012. - 3D Traction Forces in Cancer Cell Invasion
In PloS One, volume 7, number 3, pp. e33476, 2012. - Parameter-Free Binarization and Skeletonization of Fiber Networks from Confocal Image Stacks
In PLoS ONE, volume 7, number 5, pp. e36575 pp.1–8, 2012. - Cellular Mechano-Stimulation by Adjusting the Viscous Drag of Cell-Substrate Linkers in Biomembrane-Mimicking Cell Substrates
Biophysical Journal 102 (3), 565a, 2012, 2012. - Akt and p53 are potential mediators of reduced mammary tumor growth by Chloroquine and the mTOR inhibitor RAD001
In Biochem Pharmacol, volume 83, number 4, pp. 480–8, 2012. - Inhomogeneous ensembles of correlated random walkers
In arXiv, 2012. - Estimation of Cellular Forces during Migration through Non-Linear and Non-Affine Collagen Networks
Biophysical Journal 102 (3), 220a, 2012, 2012. - NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migration
In PLoS One, volume 7, number 4, pp. e35058, 2012.
2011
2011
- Conformational Switch of Vinculin: a Prerequisite for Mechanical Force Transmission
MOLECULAR BIOLOGY OF THE CELL 22, 2011, 2011. - Head/tail interaction of vinculin influences cell mechanical behavior
In Biochem Biophys Res Commun, volume 406, number 1, pp. 85–8, 2011. - Focal Adhesion Kinase Stabilizes the Cytoskeleton
In Biophys J, volume 101, pp. 2131–2138, 2011. - Calcium imaging in the optical stretcher
In OPTICS EXPRESS, volume 19, number 20, pp. 19212–19222, 2011. - Control of magnesium corrosion and biocompatibility with biomimetic coatings
In J Biomed Mater Res B Appl Biomater, volume 96, number 1, pp. 84–90, 2011. - Linear and Nonlinear Rheology of Living Cells
In Annu Rev Mater Res, volume 41, pp. 75–97, 2011. - Nonlinear viscoelasticity of adherent cells is controlled by cytoskeletal tension
In Soft Matter, volume 7, pp. 3127–3132, 2011. - Transfection with fluorescent constructs impairs the mechanical behavior of cells.
MOLECULAR BIOLOGY OF THE CELL 22, 2011, 2011. - Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis
In Embo J, volume 30, number 22, pp. 4539–53, 2011. - Antitumoröser Effekt von Chloroquin und RAD001 in vitro und in einem Mammakarzinom MCF7 Xenograft Mausmodell
Senologie-Zeitschrift für Mammadiagnostik und-therapie 8 (02), A117, 2011, 2011. - Characterization of collagen gel pore sizes from confocal reflection images
MOLECULAR BIOLOGY OF THE CELL 22, 2011, 2011. - Poresizes in random line networks
In arXiv:1110.1803v1, 2011. - The GPI-Anchored Receptor CD24 Increases Cancer Cell Invasion through Enhanced Contractile Forces
Biophysical Journal 100 (3), 600a, 2011, 2011. - The Integrins α5β1 and α2β1 Enhance Cell Motility
Biophysical Journal 100 (3), 599a, 2011, 2011. - Mechano-stimulation of fibroblasts by adjusting viscous drag of mobile cell linkers in biomembrane-mimicking substrates
Biophysical Journal 100 (3), 440a, 2011, 2011. - Time-Resolved Observation of Neutrophile Migration Through Three-Dimensional Matrices
Biophysical Journal 100 (3), 306a, 2011, 2011. - Proliferationshemmung und Reduktion der RAD001-induzierten Akt-Phosphorylierung durch Chloroquin in MCF7 Mammakarzinomzellen
Geburtshilfe und Frauenheilkunde 71 (05), P520, 2011, 2011. - Corrosion of Mg alloy AZ91D in the presence of living cells
Journal of Biomedical Materials Research Part B: Applied Biomaterials 99 (2 …, 2011, 2011. - Corrosion, surface modification, and biocompatibility of Mg and Mg alloys
Magnesium Technology 2011, 409-412, 2011, 2011. - Coordinated movements prevent jamming in an Emperor penguin huddle
In PloS One, volume 6, pp. e20260, 2011.
2010
2010
- The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
In Cell Commun Signaling, 2010. - Anodic mesoporous TiO(2) layer on Ti for enhanced formation of biomimetic hydroxyapatite
In Acta Biomater, 2010. - Nonlinear mechanical response of adherent cells measured by magnetic bead microrheology
Bone 46, S50-S51, 2010, 2010. - Fluctuations of cytoskeleton-bound microbeads - the effect of bead-receptor binding dynamics
In J Phys Condens Matter, volume 22, pp. 194105, 2010. - Breast cancer cells reduce the stiffness of endothelial cells
Biophysical Journal 98 (3), 731a-732a, 2010, 2010. - Integrin alpha5beta1 facilitates cancer cell invasion through enhanced contractile forces
In J Cell Sci, volume 124, number Pt 3, pp. 369–83, 2010. - Vinculin facilitates cell invasion into three-dimensional collagen matrices
In J Biol Chem, volume 285, number 17, pp. 13121–30, 2010. - Non-linear mechanical properties of collagen networks during cyclic loading
Biophysical Journal 98 (3), 558a-559a, 2010, 2010. - Size-selective separation of macromolecules by nanochannel titania membrane with self-cleaning (declogging) ability
In J Am Chem Soc, volume 132, number 23, pp. 7893–5, 2010. - Pulling it together in three dimensions
In Nat Methods, volume 7, number 12, pp. 963–5, 2010. - Image Processing in Polar Science-how to find and observe whales and penguins.
2010.
2009
2009
- Anchorage of vinculin to lipid membranes influences cell mechanical properties
In Biophys J, volume 97, pp. 3105–3112, 2009. - A Blind Spot in Confocal Reflection Microscopy: The Dependence of Fiber Brightness on Fiber Orientation in Imaging Biopolymer Networks
In Biophys J, volume 98, pp. L01–L03, 2009. - Filamin A is essential for active cell stiffening but not passive stiffening under external force
In Biophys J, volume 96, pp. 4326–4335, 2009. - Active soft glassy rheology of adherent cells
In Soft Matter RSC, volume 5, pp. 1771–74, 2009. - Contractile prestress controls stiffening and fluidization of living cells in response to large external forces
In arXiv, 2009. - Strain Stiffening And Soft Glassy Rheology In A Generalized Sliding Filament Model
Biophysical Journal 96 (3), 522a, 2009, 2009. - Effect of surface pre-treatments on biocompatibility of magnesium
In Acta Biomater, volume 5, number 7, pp. 2783–9, 2009. - Noise and critical phenomena in biochemical signaling cycles at small molecule numbers
In Phys Rev E, volume 80, pp. 021915, 2009. - Single-cell response to stiffness exhibits muscle-like behavior
In Proc Natl Acad Sci U S A, volume 106, number 43, pp. 18243–8, 2009. - Neutrophil morphology and migration are affected by substrate elasticity
In Blood, volume 114, number 7, pp. 1387–95, 2009. - Neutrophil mechanosensing
Cytokine 48 (1), 79, 2009, 2009. - Influence of chemical surface modification on corrosion and biocompatibility of magnesium
Electrochemical Society Meeting Abstracts 216, 1869-1869, 2009, 2009.
2008
2008
- Cell migration through connective tissue in 3-D
APS March Meeting Abstracts, Q16. 001, 2008, 2008. - Hydrodynamic thickening of lubricating fluid layer beneath sliding mesothelial tissues
In J Biomech, volume 41, number 6, pp. 1197–205, 2008. - Robust Pore Size Analysis of Filamentous Networks From 3D Confocal Microscopy
In Biophys J, volume 95, pp. 6072–80, 2008. - Breakdown of the endothelial barrier function in tumor cell transmigration
In Biophys J, volume 94, number 7, pp. 2832–46, 2008. - Contractile forces in tumor cell migration
In Eur J Cell Biol, volume 87, number 8-9, pp. 669–76, 2008. - Mechano-coupling and regulation of contractility by the vinculin tail domain.
In Biophys J, volume 94, number 2, pp. 661–70, 2008. - Regulation of cell contractility through vinculin and its domains.
2008. - Up-regulation of Rho/ROCK Signaling in Sarcoma Cells Drives Invasion and Increased Generation of Protrusive Forces
In Mol Cancer Res, volume 6, number 9, pp. 1410–20, 2008. - CD24 induces localization of beta1 integrin to lipid raft domains
In Biochem Biophys Res Commun, volume 365, number 1, pp. 35–41, 2008. - Superdiffusive Motion With Fractional Power‐Law Exponents
AIP Conference Proceedings 1027 (1), 624-626, 2008, 2008. - Magnetically Guided Titania Nanotubes for Site-Selective Photocatalysis and Drug Release
In Angewandte Chemie, volume 120, pp. 1–5, 2008. - Large amplitude oscillatory shear in collagen rheology shows early strain stiffening
Journal of Biomechanics 41, S318, 2008, 2008.
2007
2007
- Cytoskeleton dynamics: Fluctuations within the network
In Biochem Biophys Res Commun, volume 355, pp. 324–30, 2007. - KS, and Stephens, NL 1979. Mechanical alterations of airway smooth muscle in a canine asthmatic model. J. Appl. Physiol.
Canadian Journal of Physiology and Pharmacology 85 (7-12), 709, 2007, 2007. - Mechanotransduction, asthma, and airway smooth muscle
In Drug Discovery Today, volume 4, number 3, pp. 131–37, 2007. - Single cell biornechanics and progression of cancer
EUROPEAN JOURNAL OF CELL BIOLOGY 86, 12-12, 2007, 2007. - Focal Adhesion Kinase (FAK): a cellular force transducer?
EUROPEAN JOURNAL OF CELL BIOLOGY 86, 13-13, 2007, 2007. - Cell tractions during tumor cell invasion in 3-D collagen gels
BIOPHYSICAL JOURNAL, 636A-636A, 2007, 2007. - High-Force Magnetic Tweezers with Force Feedback for Biological Applications
In Rev Sci Instrum, volume 78, pp. 114301–1–6, 2007. - Emergence of non-Brownian fluctuations in stress fiber networks
BIOPHYSICAL JOURNAL, 632A-632A, 2007, 2007. - Simple model of cytoskeletal fluctuations
In Phys Rev E, volume 76, number 021925, pp. 021925–1–12, 2007. - Traction forces and cytoskeletal dynamics determine invasiveness of human breast carcinoma cells
BIOPHYSICAL JOURNAL, 631A-631A, 2007, 2007. - Vinculin head and tail domains control focal adhesion forces and cell mechanical behavior
BIOPHYSICAL JOURNAL, 175A-175A, 2007, 2007. - Airway Hyperresponsiveness, Remodeling, and Smooth Muscle Mass: Right Answer, Wrong Reason?
In Am J Respir Cell Mol Biol, volume 37, number 3, pp. 264–72, 2007. - Stress fluctuations and motion of cytoskeletal-bound markers
In Phys Rev E Stat Nonlin Soft Matter Phys, volume 76, number 1 Pt 1, pp. 011918, 2007. - Superdiffusivity and directionality in cytoskeletal remodeling
BIOPHYSICAL JOURNAL, 636A-636A, 2007, 2007. - Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
In Eur Respir J, volume 29, number 5, pp. 834–60, 2007. - Rate of stress increase during cell spreading on substrates with different matrix rigidity
2007.
2006
2006
- Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness?
In Am J Respir Cell Mol Biol, volume 35, number 1, pp. 55–64, 2006. - The cytoskeleton as a soft glassy material. In: Cytoskeletal Mechanics: Models and Measurements.
2006. - Force generated by the isolated smooth muscle cell in a three-dimensional collagen gel
Journal of Biomechanics 39, S234, 2006, 2006. - Linearity and superposition of cell mechanical properties
Journal of Biomechanics 39, S236, 2006, 2006. - Increased cytoskeletal dynamics of invasive vs. non-invasive tumor cells
Journal of Biomechanics 39, S229, 2006, 2006. - Kraftmessung an Zellen in 2D und 3D.
2006. - Correlated particle motion in an endothelial cell monolayer
Journal of Biomechanics 39, S581, 2006, 2006. - Force fluctuation and microrehology in endothelial cells
Journal of Biomechanics Vol. 39Supplement 1, Page S231, 2006, 2006. - Long range correlation of force fluctuation in an endothelial cell layer
ELSEVIER SCI LTD, 2006, 2006.
2005
2005
- Cytoskeletal remodelling and slow dynamics in the living cell
In Nat Mater, volume 4, number 7, pp. 557–61, 2005. - Rat airway smooth muscle cell during actin modulation: rheology and glassy dynamics
In Am J Physiol Cell Physiol, volume 289, number 6, pp. C1388–95, 2005.
2004
2004
- Role of Heat Shock Protein 27 in Cytoskeletal Remodeling of the Airway Smooth Muscle Cell
In J Appl Physiol, volume 96, number 5, pp. 1701–1713, 2004. - On the terminology for describing the length-force relationship and its changes in airway smooth muscle
In J Appl Physiol, volume 97, number 6, pp. 2029–34, 2004. - Localized mechanical stress induces time-dependent actin cytoskeletal remodeling and stiffening in cultured airway smooth muscle cells
In Am J Physiol Cell Physiol, volume 287, number 2, pp. C440–8, 2004. - Universal mechanical behavior of airway smooth muscle even at the extremes of actin modulation
BIOPHYSICAL JOURNAL 86 (1), 567A-568A, 2004, 2004. - Linearity and time-scale invariance of the creep function in living cells.
In J Royal Soc Interface, volume 1, number 1, pp. 91–97, 2004. - Cytoskeletal mechanics in adherent human airway smooth muscle cells: probe specificity and scaling of protein-protein dynamics
In Am J Physiol Cell Physiol, volume 287, number 3, pp. C643–54, 2004. - Rheology of airway smooth muscle cells is associated with cytoskeletal contractile stress
In J Appl Physiol, volume 96, number 5, pp. 1600–5, 2004.
2003
2003
- Microrheology of human lung epithelial cells measured by atomic force microscopy
In Biophys J, volume 84, number 3, pp. 2071–9., 2003. - Fractional derivatives embody essential features of cell rheological behavior
In Ann Biomed Eng, volume 31, number 6, pp. 692–9, 2003. - Remodeling of the airway smooth muscle cell: are we built of glass?
In Respir Physiol Neurobiol, volume 137, number 2-3, pp. 109–24, 2003. - Time scale and other invariants of integrative mechanical behavior in living cells
In Phys. Rev. E, volume 68, pp. 041914, 2003. - Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells
In Am J Physiol Cell Physiol, volume 285, number 5, pp. C1082–90, 2003. - Oscillatory magnetic tweezers based on ferromagnetic beads and simple coaxial coils
In Rev Sci Instrum, volume 74, pp. 4012–4020, 2003.
2002
2002
- Traction fields, moments, and strain energy that cells exert on their surroundings
In Am J Physiol Cell Physiol, volume 282, number 3, pp. C595–605., 2002. - Dynamic equilibration of airway smooth muscle contraction during physiological loading
In J Appl Physiol, volume 92, number 2, pp. 771–9, 2002. - A finite element model of cell deformation during magnetic bead twisting
In J Appl Physiol, volume 93, number 4, pp. 1429–36., 2002.
2001
2001
- Twisting integrin receptors increases endothelin-1 gene expression in endothelial cells
In Am J Physiol Cell Physiol, volume 280, number 6, pp. C1475–84., 2001. - Is Cell Rheology Governed by a Glass Transition?
ASME-PUBLICATIONS-BED 50, 813-814, 2001, 2001. - Scaling the microrheology of living cells
In Phys Rev Lett, volume 87, number 14, pp. 148102., 2001. - A simple scaling law governs complex cell rheology
Faseb Journal, 2001, 2001. - Time course and heterogeneity of contractile responses in cultured human airway smooth muscle cells
In J Appl Physiol, volume 91, number 2, pp. 986–94., 2001.
2000
2000
- Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer
In Biochem Biophys Res Commun, volume 277, number 1, pp. 93–9., 2000. - innovative techniques
J Appl Physiol 89, 1619-1632, 2000, 2000. - Mechanical properties of cultured human airway smooth muscle cells from 0.05 to 0.4 Hz
In J Appl Physiol, volume 89, number 4, pp. 1619–32., 2000. - Mechanical control of cyclic AMP signalling and gene transcription through integrins
In Nat Cell Biol, volume 2, number 9, pp. 666–8., 2000.
1999
1999
- Dynamic delay time compensation for sampling capillaries used in respiratory mass spectrometry
In Technol Health Care, volume 7, number 4, pp. 243–59, 1999. - Dynamically equilibrated states of airway smooth muscle during breathing: Bridge dynamics or sarcomere dynamics?
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 159 (3), A469-A469, 1999, 1999. - Implications of heterogeneous bead behavior on cell mechanical properties measured with magnetic twisting cytometry
In J Magnetism Magnetic Materials, volume 194, number 1-3, pp. 120–125, 1999. - Measurement of cytoplasmic viscosity in neutrophils between 0.1 Ha and 300 Hz
MOLECULAR BIOLOGY OF THE CELL 10, 381A-381A, 1999, 1999. - Additional inspiratory work of breathing imposed by tracheostomy tubes and non-ideal ventilator properties in critically ill patients
In Intensive Care Med, volume 25, number 5, pp. 514–9, 1999. - Effects of deforming stress on the apparent stiffness of alveolar epithelial cells
1999 Bioengineering Conference, 519-520, 1999, 1999. - Role of ERK MAP kinases in responses of cultured human airway smooth muscle cells to IL-1beta
In Am J Physiol, volume 277, number 5 Pt 1, pp. L943–51., 1999. - Novel rheology of the human airway smooth muscle cell
Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering …, 1999, 1999.
1998
1998
- Effects of mechanical unloading/loading on respiratory loop gain and periodic breathing in man
In Respir Physiol, volume 112, number 1, pp. 23–36, 1998.
1997
1997
- Breathing pattern and additional work of breathing in spontaneously breathing patients with different ventilatory demands during inspiratory pressure support and automatic tube compensation
In Intensive Care Med, volume 23, number 5, pp. 545–52, 1997. - Respiratory comfort of automatic tube compensation and inspiratory pressure support in conscious humans
In Intensive Care Med, volume 23, number 11, pp. 1119–24, 1997. - Zusätzliche Atemarbeit bei spontanatmenden Patienten mit Tracheostomie-Kanülen
1997. - Delayed derecruitment after removal of PEEP in patients with acute lung injury
In Acta Anaesthesiol Scand, volume 41, number 6, pp. 675–84, 1997. - Support of spontaneous breathing in the intubated patient: automatic tube compensation (ATC) and proportional assist ventilation (PAV)
In Acta Anaesthesiol Scand Suppl, volume 111, pp. 123–8, 1997.
1996
1996
- Influence of mechanical loading and unloading on respiratory controller gain in healthy subjects
Intensive Care Medicine 22 (Suppl 1), S117-S117, 1996, 1996. - [Added work of breathing, respiratory pattern and determination of ventilator weaning readiness in inspiratory pressure support and and automatic tube compensation]
In Unfallchirurg, volume 99, number 10, pp. 764–70, 1996. - Zusätzliche Atemarbeit, Atemmuster und Erkennbarkeit der Extubationsbereitschaft unter inspiratorischer Druckunterstützung (IPS) und automatischer Tubuskompensation (ATC)
Der Unfallchirurg 99 (10), 764-770, 1996, 1996. - Computerunterstütztes rückgekoppeltes Beatmungssystem: Validierung eines neuen Beatmungsmodus für eine minimale Druckbelastung
Walter de Gruyter, Berlin/New York 41 (s1), 520-521, 1996, 1996.
1995
1995
- An analysis of desynchronization between the spontaneously breathing patient and ventilator during inspiratory pressure support
In Chest, volume 107, number 5, pp. 1387–94, 1995. - Limitations of Pressure Support Ventilation in Patients with High Ventilatory Demand
CLINICAL INTENSIVE CARE 6, 7-7, 1995, 1995. - Time constant/volume relationship of passive expiration in mechanically ventilated ARDS patients
In Eur Respir J, volume 8, number 1, pp. 114–20, 1995. - Closed-loop-Kontrolle des Trachealdrucks intubierter Patienten bei druckunterstützter Spontanatmung
Respiratorische Therapie nach operativen Eingriffen, 564-596, 1995, 1995.
1994
1994
- Automatic compensation of endotracheal tube resistance in spontaneously breathing patients
In Technol Health Care, volume 1, number 4, pp. 281–91, 1994. - Optimierung der Druckunterstützung spontanatmender intubierter Patienten unter mechanischer Ventilation: theoretische, experimentelle und klinische Untersuchungen
1994. - Treatment of patient-ventilator desynchronization with automatic tube compensation (ATC) and propoertional assist ventilation
In Int Care Med, volume 20, number Suppl. 2, pp. 38, 1994. - Determination of volume-dependent respiratory system mechanics in mechanically ventilated patients using the new SLICE method
Technology and Health Care 2 (3), 175-191, 1994, 1994. - Automatische Tubus-Kompensation mit volumen-und flussproportionaler Druckunterstützung-" ATC with VPPS and FPPS
G. Thieme Verlag Stuttgart, 1994, 1994.
1993
1993
- Continuous calculation of intratracheal pressure in tracheally intubated patients
In Anesthesiology, volume 79, number 3, pp. 503–13, 1993.
1992
1992