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Andrea Malandrino

Andrea Malandrino

Andrea’s research interests include tissue and cell biomechanics and mechanobiology, especially focusing on the dynamics of extracellular matrices. Recent works have included vascularized microphysiological 3D platforms (e.g. using microfluidics) for modeling disease aspects, and for investigating biomechanical aspects and patterning in organogenesis. His research combines both experimental “wet” and computational/theoretical “dry” approaches.

[17] M. H. Esteki, A. Malandrino, A. A. Alemrajabi, G. K. Sheridan, G. Charras, E. Moeendarbary
Poroelastic osmoregulation of living cell volume
In iScience, volume 24, 2021. [bibtex] [pdf] [doi]
[16] O. Tura-Ceide, Vfed Smolders, N. Aventin, C. Moren, M. Guitart-Mampel, I. Blanco, L. Piccari, J. Osorio, C. Rodriguez, M. Rigol, N. Solanes, A. Malandrino, K. Kurakula, M. J. Goumans, P. H. A. Quax, V. I. Peinado, M. Castella, J. A. Barbera
Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension
In Sci Rep, volume 11, 2021. [bibtex] [pdf] [doi]
[15] A. Malandrino, X. Trepat, R. D. Kamm, M. Mak
Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices
In PLoS Comput Biol, volume 15, 2019. [bibtex] [pdf] [doi]
[14] Y. L. Han, P. Ronceray, G. Xu, A. Malandrino, R. D. Kamm, M. Lenz, C. P. Broedersz, M. Guo
Cell contraction induces long-ranged stress stiffening in the extracellular matrix
In Proc Natl Acad Sci U S A, volume 115, 2018. [bibtex] [pdf] [doi]
[13] A. Malandrino, R. D. Kamm, E. Moeendarbary
In Vitro Modeling of Mechanics in Cancer Metastasis
In ACS Biomater Sci Eng, volume 4, 2018. [bibtex] [pdf] [doi]
[12] A. Malandrino, M. Mak, R. D. Kamm, E. Moeendarbary
Complex mechanics of the heterogeneous extracellular matrix in cancer
In Extreme Mech Lett, volume 21, 2018. [bibtex] [pdf] [doi]
[11] R. Blanchard, C. Morin, A. Malandrino, A. Vella, Z. Sant, C. Hellmich
Patient-specific fracture risk assessment of vertebrae: A multiscale approach coupling X-ray physics and continuum micromechanics
In Int J Numer Method Biomed Eng, volume 32, 2016. [bibtex] [pdf] [doi]
[10] A. Malandrino
Models and Experiments in Bioengineering: Why Synergies Are Encouraged
In Front Bioeng Biotechnol, volume 3, 2015. [bibtex] [pdf] [doi]
[9] A. Malandrino, J. M. Pozo, I. Castro-Mateos, A. F. Frangi, M. M. van Rijsbergen, K. Ito, H. J. Wilke, T. T. Dao, M. C. Ho Ba Tho, J. Noailly
On the relative relevance of subject-specific geometries and degeneration-specific mechanical properties for the study of cell death in human intervertebral disk models
In Front Bioeng Biotechnol, volume 3, 2015. [bibtex] [pdf] [doi]
[8] A. Malandrino, D. Lacroix, C. Hellmich, K. Ito, S. J. Ferguson, J. Noailly
The role of endplate poromechanical properties on the nutrient availability in the intervertebral disc
In Osteoarthritis Cartilage, volume 22, 2014. [bibtex] [pdf] [doi]
[7] A. Malandrino, J. Noailly, D. Lacroix
Numerical exploration of the combined effect of nutrient supply, tissue condition and deformation in the intervertebral disc
In J Biomech, volume 47, 2014. [bibtex] [pdf] [doi]
[6] A. Malandrino, J. Noailly, D. Lacroix
Regional annulus fibre orientations used as a tool for the calibration of lumbar intervertebral disc finite element models
In Comput Methods Biomech Biomed Engin, volume 16, 2013. [bibtex] [pdf] [doi]
[5] A. Malandrino, J. Noailly, D. Lacroix
The effect of sustained compression on oxygen metabolic transport in the intervertebral disc decreases with degenerative changes
In PLoS Comput Biol, volume 7, 2011. [bibtex] [pdf] [doi]
[4] F. Galbusera, H. Schmidt, J. Noailly, A. Malandrino, D. Lacroix, H. J. Wilke, A. Shirazi-Adl
Comparison of four methods to simulate swelling in poroelastic finite element models of intervertebral discs
In J Mech Behav Biomed Mater, volume 4, 2011. [bibtex] [pdf] [doi]
[3] A. Malandrino, J. A. Planell, D. Lacroix
Statistical factorial analysis on the poroelastic material properties sensitivity of the lumbar intervertebral disc under compression, flexion and axial rotation
In J Biomech, volume 42, 2009. [bibtex] [pdf] [doi]
[2] E. Schileo, E. Dall'ara, F. Taddei, A. Malandrino, T. Schotkamp, M. Baleani, M. Viceconti
An accurate estimation of bone density improves the accuracy of subject-specific finite element models
In J Biomech, volume 41, 2008. [bibtex] [pdf] [doi]
[1] E. Schileo, F. Taddei, A. Malandrino, L. Cristofolini, M. Viceconti
Subject-specific finite element models can accurately predict strain levels in long bones
In J Biomech, volume 40, 2007. [bibtex] [pdf] [doi]