Natural killer (NK) cells are important effector cells in the immune response to cancer. Clinical trials on adoptively transferred NK cells in patients with solid tumors, however, have thus far been unsuccessful. As NK cells need to pass stringent safety evaluation tests before clinical use, the cel... 

In-vitro engineered cardiac tissue grafts are of growing interest for different applications such as substituting scarred myocardial tissue after infarction or chronic cardiomyopathies, or as a drug testing platform. Several studies have recently reported successful fabrication of microtissues from s... 

Cell migration through a three-dimensional (3-D) matrix depends strongly on the ability of cells to generate traction forces. To overcome the steric hindrance of the matrix, cells need to generate sufficiently high traction forces but also need to distribute these forces spatially in a migration-pro... 

Metastases occur when tumour cells detach from the primary tumour and migrate to distant sites through the connective tissue of organs. During this migration process, the tumour cells generate mechanical forces in order to overcome the resistance of the connective tissue or to change their shape so ...