Bronchoscopy in ventilated patients severely narrows the endotracheal tube lumen and increases resistance, which can lead to hypoventilation and intrinsic PEEP build-up. These ventilation impairments depend on the geometry of the tube-bronchoscope combination, ventilator settings, and patient mechan... 

Durotaxis—cell migration along stiffness gradients—is implicated in development, repair, and disease, though its in vivo role remains unclear. We show that durotaxis actively drives disease progression in mouse models of lung fibrosis (IPF) and metastatic pancreatic cancer. In fibrosis, it guides fi... 

Biofouling is a global issue that affects almost all water-based processes across various industries and significantly impacts our daily lives. Conventional biofouling treatments, such as toxic paints or antibiotics, have substantial limitations and challenges. These include the emergence of resista... 

Aerophilic surfaces immersed underwater trap films of air known asplastron. Plastron has typically been considered impractical forunderwater engineering applications due to their metastable performance.Here, we describe aerophilic titanium alloy (Ti) surfaces with extendedplastron lifetimes that are... 

Vimentin is a highly charged intermediate filament protein that inherently forms extended dimeric coiled-coils, which serve as the basic building blocks of intermediate filaments. Under low ionic strength conditions, vimentin filaments dissociate into uniform tetrameric complexes of two anti-paralle... 

Numerous cell functions are accompanied by phenotypic changes in viscoelastic properties, and measuring them can help elucidate higher-level cellular functions in health and disease. We present a high-throughput, simple and low-cost microfluidic method for quantitatively measuring the elastic (stora... 

During bioprinting, cells are suspended in a viscous bioink and extruded under pressure through small diameter printing needles. The combination of high pressure and small needle diameter exposes cells to considerable shear stress, which can lead to cell damage and death. Approaches to monitor and c... 

Physiological and pathological cardiac stress induced by exercise and hypertension, respectively, increase the hemodynamic load for the heart and trigger specific hypertrophic signals in cardiomyocytes leading to adaptive or maladaptive cardiac hypertrophy responses involving a mechanosensitive remo... 

Desminopathies comprise hereditary myopathies and cardiomyopathies caused by mutations in the intermediate filament protein desmin that lead to severe and often lethal degeneration of striated muscle tissue. Animal and single cell studies hinted that this degeneration process is associated with mass... 

Chemotaxis enables cells to systematically approach distant targets that emit a diffusible guiding substance. However, the visual observation of an encounter between a cell and a target does not necessarily indicate the presence of a chemotactic approach mechanism, as even a blindly migrating cell c... 

Cellular force generation and force transmission are of fundamental importance for numerous biological processes and can be studied with the methods of Traction Force Microscopy (TFM) and Monolayer Stress Microscopy. Traction Force Microscopy and Monolayer Stress Microscopy solve the inverse problem... 

Rheologic models consisting of combinations of linear elements, such as and dashpots, are widely used in biophysics to describe the mechanical and, in particular, the viscoelastic behavior of proteins, cells, tissue, and soft matter. Even simple arrangements with few elements often suffice to recapi... 

Cells in the lungs, the heart, and numerous other organs, are constantly exposed to dynamic forces and deformations. To mimic these dynamic mechanical loading conditions and to study the resulting cellular responses such as morphological changes or the activation of biochemical signaling pathways, c... 

Natural killer (NK) cells are important effector cells in the immune response to cancer. Clinical trials on adoptively transferred NK cells in patients with solid tumors, however, have thus far been unsuccessful. As NK cells need to pass stringent safety evaluation tests before clinical use, the cel... 

Camera traps for motion-triggered or continuous time-lapse recordings are readily available on the market. For demanding applications in ecology and environmental sciences, however, commercial systems often lack flexibility to freely adjust recording time intervals, suffer from mechanical component w...