Janina Lange

-Geometrical characterization of artificial extracellular matrices consisting of reconstituted collagen I

-Influence of collagen concentration and crosslinkers on pore size distribution

Thermal Noise Imaging: observing the topology of collagen networks (2012)

-Cooperation with Prof. E.-L. Florin, University of Texas at Austin

-Adaptation of TNI for investigations on 3D, wet samples, e.g. collagen networks

Collective cell migration (2012-2013)

-Cooperation with PD Pamela Strissel, PhD at University Clinics, Erlangen

-Correlation of macroscopic growth of artificial tumor cell colonies with collective migration of cells

Cell rheology measurements with microfluidic devices (2013-2017)

-Cooperation with Prof. Graeme Whyte, Heriot-Watt University, Edinburgh

-Practical and theoretical development of a microfluidic measurement tool to investigate cell stiffness and fluidity in a high-throughput, quantitative way

-Biological application of the setup in many national and international collaborations

-PhD in biophysics, (2013-2017)

-Physics (M.Sc.) , 2013

-Physics (B.Sc.) , 2011

Dr.-Johanna-Decker-Gymnasium, Amberg:

Abitur,  (2008)

Annual meeting of the German biophysical society, Erlangen, Germany,

2016/10/04-2016/10/06:

Janina R. Lange, Claus Metzner, Sebastian Richter, Werner Schneider, Monika Spermann, Thorsten Kolb, Graeme Whyte, Ben Fabry

Unbiased high precision cell mechanical measurements with microconstrictions

Physics of Cancer, (7th Annual Meeting), Leipzig, Germany, 2016/10/04-2016/10/06:

Janina R. Lange, Claus Metzner, Sebastian Richter, Werner Schneider, Monika Spermann, Thorsten Kolb, Graeme Whyte, Ben Fabry

Unbiased high precision cell mechanical measurements with microconstrictions

Biophysical Society 60th Meeting, Los Angeles, USA, 2016/02/27-2016/03/02:

Janina R. Lange, Julian Steinwachs, Claus Metzner, Graeme Whyte, Ben Fabry

Cell mechanical properties measured with micron-scale constrictions: influence of pressure, strain, and culture conditions

6th European Cell Mechanics Meeting, Barcelona, Spain, 2015/05/13-2015/05/15:

Janina R. Lange, Julian Steinwachs, Thorsten Kolb, Lena A. Lautscham, Irina Harder, Graeme Whyte, Ben Fabry

Microconstriction arrays for high throughput quantitative measurements of cell mechanical properties

Physics of Cancer, (5rd Annual Meeting), Leipzig, Germany, 2014/10/02-2014/10/05:

Janina R. Lange, Thorsten Kolb, Jonas Hallmen, Graeme Whyte, Ben Fabry

Cell deformability during passage through micron-scale constrictions

Biophysical Society 58th Meeting, San Francisco, USA, 2014/02/15-2014/02/19:

Janina R. Lange, Michael Haug, Thorsten Kolb, Sahradha Albert, Graeme Whyte, Ben Fabry

Nuclear deformability is critically dependent on Lamin A/B

5th European Cell Mechanics Meeting, Obergurgel, Austria, 2013/09/28-2013/10/02:

Janina R. Lange, Claus Metzner, Patrick Krauss, Pamela Strissel, Ben Fabry

Collective Migration during the Growth of mesenchymal and epithelial cell colonies

Annual Meeting of the German Physical Society (DPG), Regensburg, Germany, 2013/03/11-2013/03/15

Janina R. Lange, Claus Metzner, Patrick Krauss, Pamela Strissel, Ben Fabry

The role of collective cell migration during tumor growth

Patrick Krauss, Claus Metzner, Janina Lange, Ben Fabry

Physics of Emergent Behavior (IOP), Brighton, GB, 2013/06/23-2013/06/26:

Janina R. Lange, Claus Metzner, Patrick Krauss, Pamela Strissel, Ben Fabry

Collective migration during the growth of epithelial and mesenchymal cell colonies, Poster Prize

Patrick Krauss, Claus Metzner, Janina R. Lange, Ben Fabry

Emergence of cell colony dynamics from proliferating particles with Lennard-Jones like interactions

Biophysical Society 57th Meeting, Philadelphia, USA, 2013/02/02-2013/02/06

Tobias F. Bartsch, Martin D. Kochanczyk, Janina R. Lange, Ernst-Ludwig Florin

Three-dimensional thermal noise imaging of collagen networks

Physics of Cancer (3rd Annual Meeting), Leipzig, Germany, 2012/11/01-2012/11/03

Janina R. Lange, Claus Metzner, Julian Steinwachs, Pamela Strissel, Ben Fabry

3D topology of tumor cell colonies on a 2D substrate

2017

• Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions
  Lange, J. R.; Metzner, C.; Richter, S.; Schneider, W.; Spermann, M.; Kolb, T.; Whyte, G.; Fabry, B.
  In Biophys J, volume 112, number 7, pp. 1472-1480, 2017. [bibtex] [pdf] [doi]

2016

• Nanoscopic imaging of thick heterogeneous soft-matter structures in aqueous solution
  Bartsch, T. F.; Kochanczyk, M. D.; Lissek, E. N.; Lange, J. R.; Florin, E. L.
  In Nat Commun, volume 7, pp. 12729, 2016. [bibtex] [pdf] [doi]

2015

• Microconstriction Arrays for High-Throughput Quantitative Measurements of Cell Mechanical Properties
  Lange, J. R.; Steinwachs, J.; Kolb, T.; Lautscham, L. A.; Harder, I.; Whyte, G.; Fabry, B.
  In Biophys J, volume 109, number 1, pp. 26-34, 2015. [bibtex] [pdf] [doi]
• Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness
  Lautscham, L. A.; Kammerer, C.; Lange, J. R.; Kolb, T.; Mark, C.; Schilling, A.; Strissel, P. L.; Strick, R.; Gluth, C.; Rowat, A. C.; Metzner, C.; Fabry, B.
  In Biophys J, volume 109, number 5, pp. 900-13, 2015. [bibtex] [pdf] [doi]

2013

• Influence of focal adhesion kinase on the mechanical behavior of cell populations
  Lange, J.; Auernheimer, V.; Strissel, P. L.; Goldmann, W. H.
  In Biochem Biophys Res Commun, 2013. [bibtex] [pdf] [doi]
• Cell and tissue mechanics in cell migration
  Lange, J. R.; Fabry, B.
  In Exp Cell Res, volume 319, number 16, pp. 2418-23, 2013. [bibtex] [pdf] [doi]
• Estimating the 3D pore size distribution of biopolymer networks from directionally biased data
  Lang, N.R.; Muenster, S.; Metzner, C.; Krauss, K.; Schuermann, S.; Lange, J.; Aifantis, K.E.; Friedrich, O.; Fabry, B.
  In Biophys J, volume 105, pp. 1967-1975, 2013. [bibtex] [pdf]

2012

• Parameter-Free Binarization and Skeletonization of Fiber Networks from Confocal Image Stacks
  Krauss, P.; Metzner, C.; Lange, J.; Lang, N.; Fabry, B.
  In PLoS ONE, volume 7, number 5, pp. e36575 pp.1-8, 2012. [bibtex] [pdf]