Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer cell invasion. Here we report that ATRA, an acti... 

Metastases occur when tumour cells detach from the primary tumour and migrate to distant sites through the connective tissue of organs. During this migration process, the tumour cells generate mechanical forces in order to overcome the resistance of the connective tissue or to change their shape so ... 

Search and rescue teams routinely use Bayesian updating to track down crashed airplanes or sunken ships: they draw a map with a first guess of the most probable locations and then continuously update the probability map as new information comes in. Physicists from the University of Erlangen-Nurember...