Links zu weiteren Portalen

Seiteninterne Suche

Bachelor/Master Projects

Ben Fabry

 

Prof. Dr. Ben Fabry

Our laboratory studies the mechanical behavior of cells, including cell adhesion, spreading, deformation, motion, migration, invasion, stiffness, viscosity, force generation and mechano-transduction. These mechanical processes are essential for many cellular functions. Abnormal cell mechanical behavior is often associated with severe disorders such as cancer or cardiovascular diseases. We collaborate with research groups worldwide to develop novel technologies that enable us to measure or apply small forces (in the pico-Newton range) and deformations (in the low nano-meter range) that are relevant for cell mechanical functions. We use these technologies to study the behavior of cells on nano-structured biomaterials, cancer cell migration in 3-dimensional biopolymer networks, or the biochemistry of adhesion proteins.

Ben Fabry studied Electrical Engineering at the Technical University of Dresden, Germany. In 1991 he joined the R&D group of the Anesthesiology and Intensive Care Medicine division at Draegerwerk AG, Luebeck, Germany, and subsequently the Department of Clinical Physiology at the University of Basel, Switzerland. After receiving his doctorate degree in Electrical Engineering in 1995, he was a research assistant, and after 1999 a research associate at the Physiology Program, Harvard School of Public Health, Boston, MA, where he worked on smooth muscle physiology and cellular biomechanics. Since 2003, Ben Fabry has been Professor for Medical Physics and Technology at the University of Erlangen-Nuremberg, Germany, and since 2005 he has been the administrative head of the Center for Medical Physics and Technology at the University.

2018
[137] C. Scholtysek, N. Ipseiz, C. Bohm, B. Krishnacoumar, M. Stenzel, T. Czerwinski, K. Palumbo-Zerr, T. Rothe, D. Weidner, A. Klej, C. Stoll, J. Distler, J. Tuckermann, M. Herrmann, B. Fabry, W. H. Goldmann, G. Schett, G. Kronke
NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover
In J Bone Miner Res, volume 33, 2018. [bibtex] [pdf] [doi]
[136] C. Metzner, J. Lange, P. Krauss, N. Wunderling, J. Ubelacker, F. Martin, B. Fabry
Pressure-driven collective growth mechanism of planar cell colonies
In Journal of Physics D-Applied Physics, volume 51, 2018. [bibtex] [pdf] [doi]
[135] S. Richter, R. Gerum, A. Winterl, A. Houstin, M. Seifert, J. Peschel, B. Fabry, C. Le Bohec, D. P. Zitterbart
Phase transitions in huddling emperor penguins
In Journal of Physics D-Applied Physics, volume 51, 2018. [bibtex] [pdf] [doi]
[134] C. Mark, C. Metzner, L. Lautscham, P. L. Strissel, R. Strick, B. Fabry
Bayesian model selection for complex dynamic systems
In Nat Commun, volume 9, 2018. [bibtex] [pdf] [doi]
[133] R.C. Gerum, S. Richter, B. Fabry, C. Le Bohec, F. Bonadonna, A. Nesterova, D. P. Zitterbart
Structural organisation and dynamics in king penguin colonies
In Journal of Physics D: Applied Physics, volume 51, 2018. [bibtex] [pdf] [doi]
[132] S. Richter, R. C. Gerum, W. Schneider, B. Fabry, C. Le Bohec, D. P. Zitterbart
A remote‐controlled observatory for behavioural and ecological research: A case study on emperor penguins
In Methods in Ecology and Evolution, volume 0, 2018. [bibtex] [pdf] [doi]
2017
[131] Richard Gerum, Sebastian Richter, Alexander Winterl, Ben Fabry, Daniel Zitterbart
CameraTransform: a Scientific Python Package for Perspective Camera Corrections
In arXiv preprint arXiv:1712.07438, 2017. [bibtex] [pdf]
[130] P. Krauss, C. Metzner, A. Schilling, C. Schutz, K. Tziridis, B. Fabry, H. Schulze
Adaptive stochastic resonance for unknown and variable input signals
In Sci Rep, volume 7, 2017. [bibtex] [pdf] [doi]
[129] S. Diermeier, J. Iberl, K. Vetter, M. Haug, C. Pollmann, B. Reischl, A. Buttgereit, S. Schurmann, M. Sporrer, W. H. Goldmann, B. Fabry, F. Elhamine, R. Stehle, G. Pfitzer, L. Winter, C. S. Clemen, H. Herrmann, R. Schroder, O. Friedrich
Early signs of architectural and biomechanical failure in isolated myofibers and immortalized myoblasts from desmin-mutant knock-in mice
In Sci Rep, volume 7, 2017. [bibtex] [pdf] [doi]
[128] M. Condor, J. Steinwachs, C. Mark, J. M. Garcia-Aznar, B. Fabry
Traction Force Microscopy in 3-Dimensional Extracellular Matrix Networks
In Curr Protoc Cell Biol, volume 75, 2017. [bibtex] [pdf] [doi]
[127] P. M. Bradbury, K. Turner, C. Mitchell, K. R. Griffin, S. Middlemiss, L. Lau, R. Dagg, E. Taran, J. Cooper-White, B. Fabry, G. M. O'Neill
The focal adhesion targeting domain of p130Cas confers a mechanosensing function
In J Cell Sci, volume 130, 2017. [bibtex] [pdf] [doi]
[126] J. R. Lange, C. Metzner, S. Richter, W. Schneider, M. Spermann, T. Kolb, G. Whyte, B. Fabry
Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions
In Biophys J, volume 112, 2017. [bibtex] [pdf] [doi]
[125] J. Branis, C. Pataki, M. Sporrer, R. C. Gerum, A. Mainka, V. Cermak, W. H. Goldmann, B. Fabry, J. Brabek, D. Rosel
The role of focal adhesion anchoring domains of CAS in mechanotransduction
In Sci Rep, volume 7, 2017. [bibtex] [pdf] [doi]
2016
[124] R. C. Gerum, S. Richter, B. Fabry, D. P. Zitterbart
ClickPoints: an expandable toolbox for scientific image annotation and analysis
In Methods in Ecology and Evolution, 2016. [bibtex] [pdf] [doi]
[123] Y. Ge, Y. H. Lin, L. A. Lautscham, W. H. Goldmann, B. Fabry, C. A. Naumann
N-cadherin-functionalized polymer-tethered multi-bilayer: a cell surface-mimicking substrate to probe cellular mechanosensitivity
In Soft Matter, volume 12, 2016. [bibtex] [pdf] [doi]
[122] A. Chronopoulos, B. Robinson, M. Sarper, E. Cortes, V. Auernheimer, D. Lachowski, S. Attwood, R. Garcia, S. Ghassemi, B. Fabry, A. Del Rio Hernandez
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
In Nat Commun, volume 7, 2016. [bibtex] [pdf] [doi]
[121] N. Bonakdar, R. Gerum, M. Kuhn, M. Sporrer, A. Lippert, W. Schneider, K. E. Aifantis, B. Fabry
Mechanical plasticity of cells
In Nat Mater, volume 15, 2016. [bibtex] [pdf] [doi]
[120] S. Schurmann, S. Wagner, S. Herlitze, C. Fischer, S. Gumbrecht, A. Wirth-Hucking, G. Prolss, L. A. Lautscham, B. Fabry, W. H. Goldmann, V. Nikolova-Krstevski, B. Martinac, O. Friedrich
The IsoStretcher: An isotropic cell stretch device to study mechanical biosensor pathways in living cells
In Biosens Bioelectron, volume 81, 2016. [bibtex] [pdf] [doi]
[119] T. J. Grundy, E. De Leon, K. R. Griffin, B. W. Stringer, B. W. Day, B. Fabry, J. Cooper-White, G. M. O'Neill
Differential response of patient-derived primary glioblastoma cells to environmental stiffness
In Sci Rep, volume 6, 2016. [bibtex] [pdf] [doi]
[118] V. Wagener, A. Schilling, A. Mainka, D. Hennig, R. Gerum, M. L. Kelch, S. Keim, B. Fabry, S. Virtanen
Cell Adhesion on Surface-Functionalized Magnesium
In ACS Appl Mater Interfaces, volume 8, 2016. [bibtex] [pdf] [doi]
[117] J. Steinwachs, C. Metzner, K. Skodzek, N. Lang, I. Thievessen, C. Mark, S. Munster, K. E. Aifantis, B. Fabry
Three-dimensional force microscopy of cells in biopolymer networks
In Nat Methods, volume 13, 2016. [bibtex] [pdf] [doi]
2015
[116] R. C. Gerum, B. Fabry, C. Metzner
Emergence of Asynchronous Local Clocks in Excitable Media
In PLoS One, volume 10, 2015. [bibtex] [pdf] [doi]
[115] B. Sarker, J. Rompf, R. Silva, N. Lang, R. Detsch, J. Kaschta, B. Fabry, A. R. Boccaccini
Alginate-based hydrogels with improved adhesive properties for cell encapsulation
In Int J Biol Macromol, volume 78, 2015. [bibtex] [pdf] [doi]
[114] C. Weis, A. Hess, L. Budinsky, B. Fabry
In-Vivo Imaging of Cell Migration Using Contrast Enhanced MRI and SVM Based Post-Processing
In PLoS One, volume 10, 2015. [bibtex] [pdf] [doi]
[113] I. Thievessen, N. Fakhri, J. Steinwachs, V. Kraus, R. S. McIsaac, L. Gao, B. C. Chen, M. A. Baird, M. W. Davidson, E. Betzig, R. Oldenbourg, C. M. Waterman, B. Fabry
Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen
In FASEB J, volume 29, 2015. [bibtex] [pdf] [doi]
[112] V. Auernheimer, L. A. Lautscham, M. Leidenberger, O. Friedrich, B. Kappes, B. Fabry, W. H. Goldmann
Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission
In J Cell Sci, volume 128, 2015. [bibtex] [pdf] [doi]
[111] L. A. Lautscham, C. Kammerer, J. R. Lange, T. Kolb, C. Mark, A. Schilling, P. L. Strissel, R. Strick, C. Gluth, A. C. Rowat, C. Metzner, B. Fabry
Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness
In Biophys J, volume 109, 2015. [bibtex] [pdf] [doi]
[110] E. K. Paluch, C. M. Nelson, N. Biais, B. Fabry, J. Moeller, B. L. Pruitt, C. Wollnik, G. Kudryasheva, F. Rehfeldt, W. Federle
Mechanotransduction: use the force(s)
In BMC Biol, volume 13, 2015. [bibtex] [pdf] [doi]
[109] A. J. Licup, S. Munster, A. Sharma, M. Sheinman, L. M. Jawerth, B. Fabry, D. A. Weitz, F. C. MacKintosh
Stress controls the mechanics of collagen networks
In Proc Natl Acad Sci U S A, volume 112, 2015. [bibtex] [pdf] [doi]
[108] J. R. Lange, J. Steinwachs, T. Kolb, L. A. Lautscham, I. Harder, G. Whyte, B. Fabry
Microconstriction Arrays for High-Throughput Quantitative Measurements of Cell Mechanical Properties
In Biophys J, volume 109, 2015. [bibtex] [pdf] [doi]
[107] C. Metzner, C. Mark, J. Steinwachs, L. Lautscham, F. Stadler, B. Fabry
Superstatistical analysis and modelling of heterogeneous random walks
In Nat Comm, volume 6, 2015. [bibtex] [pdf] [doi]
[106] F.M. Hecht, J. Rheinlaender, N. Schierbaum, W. H. Goldmann, B. Fabry, T.E. Schäffer
Imaging viscoelastic properties of living cells by AFM: Power-law rheology on the nanoscale
In Soft Matter, volume 11, 2015. [bibtex] [pdf]
[105] N. R. Lang, K. Skodzek, S. Hurst, A. Mainka, J. Steinwachs, J. Schneider, K. E. Aifantis, B. Fabry
Biphasic response of cell invasion to matrix stiffness in three-dimensional biopolymer networks
In Acta Biomater, volume 13, 2015. [bibtex] [pdf] [doi]
[104] R. Buslei, P. L. Strissel, C. Henke, R. Schey, N. Lang, M. Ruebner, C. C. Stolt, B. Fabry, M. Buchfelder, R. Strick
Activation and regulation of endogenous retroviral genes in the human pituitary gland and related endocrine tumours
In Neuropathol Appl Neurobiol, volume 41, 2015. [bibtex] [pdf] [doi]
[103] N. Bonakdar, A. Schilling, M. Sporrer, P. Lennert, A. Mainka, L. Winter, G. Walko, G. Wiche, B. Fabry, W. H. Goldmann
Determining the mechanical properties of plectin in mouse myoblasts and keratinocytes
In Exp Cell Res, 2015. [bibtex] [pdf] [doi]
2014
[102] C. Mark, C. Metzner, B. Fabry
Bayesian inference of time varying parameters in autoregressive processes
In arXiv:1405.1668, 2014. [bibtex] [pdf]
[101] A. Grigore, B. Sarker, B. Fabry, A. R. Boccaccini, R. Detsch
Behavior of Encapsulated MG-63 Cells in RGD and Gelatine-Modified Alginate Hydrogels
In Tissue Eng Part A, 2014. [bibtex] [pdf] [doi]
[100] R. Silva, B. Fabry, A. R. Boccaccini
Fibrous protein-based hydrogels for cell encapsulation
In Biomaterials, volume 35, 2014. [bibtex] [pdf] [doi]
[99] D. Zitterbart, Richter S., Spiekermann G., Behrens LK., Regnery J., Fontes RP., Hänssler T., G. König-Langlo, R. Weller, B. Fabry
Are environmental factors responsible for changed breeding behaviour in emperor penguins?
In Antarctic Science, 2014. [bibtex] [pdf] [doi]
[98] L. A. Lautscham, C. Y. Lin, V. Auernheimer, C. A. Naumann, W. H. Goldmann, B. Fabry
Biomembrane-mimicking lipid bilayer system as a mechanically tunable cell substrate
In Biomaterials, volume 35, 2014. [bibtex] [pdf] [doi]
[97] R. Janostiak, J. Brabek, V. Auernheimer, Z. Tatarova, L. A. Lautscham, T. Dey, J. Gemperle, R. Merkel, W. H. Goldmann, B. Fabry, D. Rosel
CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics
In Cell Mol Life Sci, volume 71, 2014. [bibtex] [pdf] [doi]
2013
[96] W. H. Goldmann, V. Auernheimer, I. Thievessen, B. Fabry
Vinculin, cell mechanics and tumour cell invasion
In Cell Biol Int, volume 37, 2013. [bibtex] [pdf] [doi]
[95] J. J. Kim, B. Yin, C. S. Christudass, N. Terada, K. Rajagopalan, B. Fabry, D. Y. Lee, T. Shiraishi, R. H. Getzenberg, R. W. Veltri, S. S. An, S. M. Mooney
Acquisition of paclitaxel resistance is associated with a more aggressive and invasive phenotype in prostate cancer
In J Cell Biochem, volume 114, 2013. [bibtex] [pdf] [doi]
[94] C. Weis, F. Blank, A. West, G. Black, R. C. Woodward, M. R. Carroll, A. Mainka, R. Kartmann, A. Brandl, H. Bruns, E. Hallam, J. Shaw, J. Murphy, W. Y. Teoh, K. E. Aifantis, R. Amal, M. House, T. S. Pierre, B. Fabry
Labeling of cancer cells with magnetic nanoparticles for magnetic resonance imaging
In Magn Reson Med, 2013. [bibtex] [pdf] [doi]
[93] S. Munster, L. M. Jawerth, B. A. Leslie, J. I. Weitz, B. Fabry, D. A. Weitz
Strain history dependence of the nonlinear stress response of fibrin and collagen networks
In Proc Natl Acad Sci U S A, volume 110, 2013. [bibtex] [pdf] [doi]
[92] R.C. Gerum, B. Fabry, C. Metzner, M. Beaulieu, A. Ancel, D.P. Zitterbart
The origin of traveling waves in an emperor penguin huddle
In News J Phys, volume 35, 2013. [bibtex] [pdf]
[91] N.R. Lang, S. Muenster, C. Metzner, K. Krauss, S. Schuermann, J. Lange, K.E. Aifantis, O. Friedrich, B. Fabry
Estimating the 3D pore size distribution of biopolymer networks from directionally biased data
In Biophys J, volume 105, 2013. [bibtex] [pdf]
[90] P. Cai, Y. Mizutani, M. Tsuchiya, J. M. Maloney, B. Fabry, K. J. Van Vliet, T. Okajima
Quantifying cell-to-cell variation in power-law rheology
In Biophys J, volume 105, 2013. [bibtex] [pdf] [doi]
[89] S. Munster, L. M. Jawerth, B. Fabry, D. A. Weitz
Structure and mechanics of fibrin clots formed under mechanical perturbation
In J Thromb Haemost, volume 11, 2013. [bibtex] [pdf] [doi]
[88] J. Ivanovska, A. Tregubova, V. Mahadevan, S. Chakilam, M. Gandesiri, N. Benderska, B. Ettle, A. Hartmann, S. Soder, E. Ziesche, T. Fischer, L. Lautscham, B. Fabry, G. Segerer, A. Gohla, R. Schneider-Stock
Identification of DAPK as a scaffold protein for the LIMK/cofilin complex in TNF-induced apoptosis
In Int J Biochem Cell Biol, volume 45, 2013. [bibtex] [pdf] [doi]
[87] J. R. Lange, B. Fabry
Cell and tissue mechanics in cell migration
In Exp Cell Res, volume 319, 2013. [bibtex] [pdf] [doi]
[86] S. Munster, B. Fabry
A simplified implementation of the bubble analysis of biopolymer network pores
In Biophys J, volume 104, 2013. [bibtex] [pdf] [doi]
[85] L. Lautscham, C. Yu-Hung Lin, V. Auernheimer, D. Minner, W. H. Goldmann, C. A. Naumann, B. Fabry
Mechanosensing of Cells in Laminin-Fuctionalized Biomembrane-Mimicking Substrates
In Biophysical Journal, volume 104, 2013. [bibtex] [pdf] [doi]
2012
[84] P. Bradbury, B. Fabry, G. M. O'Neill
Occupy tissue: the movement in cancer metastasis
In Cell Adh Migr, volume 6, 2012. [bibtex] [pdf] [doi]
[83] J. Zhong, J. B. Baquiran, N. Bonakdar, J. Lees, Y. W. Ching, E. Pugacheva, B. Fabry, G. M. O'Neill
NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migration
In PLoS One, volume 7, 2012. [bibtex] [pdf]
[82] P. Krauss, C. Metzner, J. Lange, N. Lang, B. Fabry
Parameter-Free Binarization and Skeletonization of Fiber Networks from Confocal Image Stacks
In PLoS ONE, volume 7, 2012. [bibtex] [pdf]
[81] T.M. Koch, S. Muenster, N. Bonakdar, J.P. Buttler, B. Fabry
3D Traction Forces in Cancer Cell Invasion
In PloS One, volume 7, 2012. [bibtex] [pdf]
[80] J. Breyer, J. Samarin, M. Rehm, L. Lautscham, B. Fabry, M. Goppelt-Struebe
Inhibition of Rho kinases increases directional motility of microvascular endothelial cells
In Biochem Pharmacol, volume 83, 2012. [bibtex] [pdf]
[79] N Bonakdar, Luczak J., L. Lautscham, M. Czonstke, T.M. Koch, A. Mainka, T. Jungbauer, W.H. Goldmann, R. Schröder, B. Fabry
Biomechanical characterization of a desminopathy in primary human myoblasts
In Biochem Biophys Res Commun, volume 419, 2012. [bibtex] [pdf] [doi]
[78] C. R. Loehberg, P. L. Strissel, R. Dittrich, R. Strick, J. Dittmer, A. Dittmer, B. Fabry, W. A. Kalender, T. Koch, D. L. Wachter, N. Groh, A. Polier, I. Brandt, L. Lotz, I. Hoffmann, F. Koppitz, S. Oeser, A. Mueller, P. A. Fasching, M. P. Lux, M. W. Beckmann, M. G. Schrauder
Akt and p53 are potential mediators of reduced mammary tumor growth by Chloroquine and the mTOR inhibitor RAD001
In Biochem Pharmacol, volume 83, 2012. [bibtex] [pdf]
2011
[77] C. Metzner, P. Krauss, B. Fabry
Poresizes in random line networks
In arXiv:1110.1803v1, 2011. [bibtex]
[76] K. R. Legate, S. Takahashi, N. Bonakdar, B. Fabry, D. Boettiger, R. Zent, R. Fassler
Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis
In Embo J, volume 30, 2011. [bibtex] [pdf]
[75] B. Fabry, A. Klemm, S. Kienle, T.E. Schäffer, W. H. Goldmann
Focal Adhesion Kinase Stabilizes the Cytoskeleton
In Biophys J, volume 101, 2011. [bibtex] [pdf]
[74] M. Gyger, D. Rose, R. Stange, T. Kießling, M. Zink, B. Fabry, J. A. Käs
Calcium imaging in the optical stretcher
In OPTICS EXPRESS, volume 19, 2011. [bibtex] [pdf]
[73] P. Kollmannsberger, B. Fabry
Linear and Nonlinear Rheology of Living Cells
In Annu Rev Mater Res, volume 41, 2011. [bibtex] [pdf]
[72] Wienecke B Butler JP Fabry B Zitterbart DP
Coordinated movements prevent jamming in an Emperor penguin huddle
In PloS One, volume 6, 2011. [bibtex] [pdf]
[71] P. Kollmannsberger, C.T. Mierke, B. Fabry
Nonlinear viscoelasticity of adherent cells is controlled by cytoskeletal tension
In Soft Matter, volume 7, 2011. [bibtex] [pdf]
[70] G. Diez, V. Auernheimer, B. Fabry, W. H. Goldmann
Head/tail interaction of vinculin influences cell mechanical behavior
In Biochem Biophys Res Commun, volume 406, 2011. [bibtex] [pdf]
[69] S. Keim, J. G. Brunner, B. Fabry, S. Virtanen
Control of magnesium corrosion and biocompatibility with biomimetic coatings
In J Biomed Mater Res B Appl Biomater, volume 96, 2011. [bibtex] [pdf]
2010
[68] T. Dey, P. Roy, B. Fabry, P. Schmuki
Anodic mesoporous TiO(2) layer on Ti for enhanced formation of biomimetic hydroxyapatite
In Acta Biomater, 2010. [bibtex] [pdf]
[67] C. T. Mierke, B. Frey, M. Fellner, M. Herrmann, B. Fabry
Integrin alpha5beta1 facilitates cancer cell invasion through enhanced contractile forces
In J Cell Sci, volume 124, 2010. [bibtex] [pdf]
[66] X. Trepat, B. Fabry, J. J. Fredberg
Pulling it together in three dimensions
In Nat Methods, volume 7, 2010. [bibtex] [pdf]
[65] J. Brabek, C. T. Mierke, D. Rosel, P. Vesely, B. Fabry
The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
In Cell Commun Signaling, 2010. [bibtex] [pdf]
[64] P. Roy, T. Dey, K. Lee, D. Kim, B. Fabry, P. Schmuki
Size-selective separation of macromolecules by nanochannel titania membrane with self-cleaning (declogging) ability
In J Am Chem Soc, volume 132, 2010. [bibtex] [pdf]
[63] C. Metzner, C. Raupach, C. T. Mierke, B. Fabry
Fluctuations of cytoskeleton-bound microbeads - the effect of bead-receptor binding dynamics
In J Phys Condens Matter, volume 22, 2010. [bibtex] [pdf]
[62] C. T. Mierke, P. Kollmannsberger, D. P. Zitterbart, G. Diez, T. M. Koch, S. Marg, W. H. Ziegler, W. H. Goldmann, B. Fabry
Vinculin facilitates cell invasion into three-dimensional collagen matrices
In J Biol Chem, volume 285, 2010. [bibtex] [pdf]
2009
[61] D. Mitrossilis, J. Fouchard, A. Guiroy, N. Desprat, N. Rodriguez, B. Fabry, A. Asnacios
Single-cell response to stiffness exhibits muscle-like behavior
In Proc Natl Acad Sci U S A, volume 106, 2009. [bibtex] [pdf]
[60] L. M. Jawerth, S. Münster, D. A. Vader, B. Fabry, D. A. Weitz
A Blind Spot in Confocal Reflection Microscopy: The Dependence of Fiber Brightness on Fiber Orientation in Imaging Biopolymer Networks
In Biophys J, volume 98, 2009. [bibtex] [pdf]
[59] G. Diez, P. Kollmannsberger, C. T. Mierke, T. M Koch, H. Vali, B. Fabry, W. H. Goldmann
Anchorage of vinculin to lipid membranes influences cell mechanical properties
In Biophys J, volume 97, 2009. [bibtex] [pdf]
[58] C. Lorenz, J. G. Brunner, P. Kollmannsberger, L. Jaafar, B. Fabry, S. Virtanen
Effect of surface pre-treatments on biocompatibility of magnesium
In Acta Biomater, volume 5, 2009. [bibtex] [pdf]
[57] C. Metzner, M. Sajitz-Hermstein, M. Schmidberger, B. Fabry
Noise and critical phenomena in biochemical signaling cycles at small molecule numbers
In Phys Rev E, volume 80, 2009. [bibtex] [pdf]
[56] P. W. Oakes, D. C. Patel, N. A. Morin, D. P. Zitterbart, B. Fabry, J. S. Reichner, J. X. Tang
Neutrophil morphology and migration are affected by substrate elasticity
In Blood, volume 114, 2009. [bibtex] [pdf]
[55] K. E. Kasza, F. Nakamura, S. Hu, P. Bonakdar N. Kollmannsberger, B. Fabry, T. P. Stossel, N. Wang, D. A. Weitz
Filamin A is essential for active cell stiffening but not passive stiffening under external force
In Biophys J, volume 96, 2009. [bibtex] [pdf]
[54] P. Kollmannsberger, B. Fabry
Active soft glassy rheology of adherent cells
In Soft Matter RSC, volume 5, 2009. [bibtex] [pdf]
2008
[53] C. T. Mierke, P. Kollmannsberger, D. Paranhos-Zitterbart, J. Smith, B. Fabry, W. H. Goldmann
Mechano-coupling and regulation of contractility by the vinculin tail domain.
In Biophys J, volume 94, 2008. [bibtex] [pdf]
[52] C. T. Mierke, D. P. Zitterbart, P. Kollmannsberger, C. Raupach, U. Schlotzer-Schrehardt, T. W. Goecke, J. Behrens, B. Fabry
Breakdown of the endothelial barrier function in tumor cell transmigration
In Biophys J, volume 94, 2008. [bibtex] [pdf]
[51] N. K. Shrestha, J. M. Macak, F. Schmidt-Stein, R. Hahn, C. T. Mierke, B. Fabry, P. Schmuki
Magnetically Guided Titania Nanotubes for Site-Selective Photocatalysis and Drug Release
In Angewandte Chemie, volume 120, 2008. [bibtex] [pdf]
[50] W. Mickel, S. Muenster, L. M. Jawerth, D. A. Vader, D. A. Weitz, A. P. Sheppard, K. Mecke, B. Fabry, G. Schroeder-Turk
Robust Pore Size Analysis of Filamentous Networks From 3D Confocal Microscopy
In Biophys J, volume 95, 2008. [bibtex] [pdf]
[49] D. Rösel, J. Brabek, O. Tolde, C. T. Mierke, D. P. Zitterbart, C. Raupach, K. Bicanova, P. Kollmannsberger, D. Pankova, P. Vesely, P. Folk, B. Fabry
Up-regulation of Rho/ROCK Signaling in Sarcoma Cells Drives Invasion and Increased Generation of Protrusive Forces
In Mol Cancer Res, volume 6, 2008. [bibtex] [pdf]
[48] J. L. Lin, T. Moghani, B. Fabry, J. P. Butler, S. H. Loring
Hydrodynamic thickening of lubricating fluid layer beneath sliding mesothelial tissues
In J Biomech, volume 41, 2008. [bibtex] [pdf]
[47] C. T. Mierke, D. Rosel, B. Fabry, J. Brabek
Contractile forces in tumor cell migration
In Eur J Cell Biol, volume 87, 2008. [bibtex] [pdf]
[46] S. Runz, C. T. Mierke, S. Joumaa, J. Behrens, B. Fabry, P. Altevogt
CD24 induces localization of beta1 integrin to lipid raft domains
In Biochem Biophys Res Commun, volume 365, 2008. [bibtex] [pdf]
2007
[45] C. Raupach, D. P. Zitterbart, C. T. Mierke, C. Metzner, F. A. Muller, B. Fabry
Stress fluctuations and motion of cytoskeletal-bound markers
In Phys Rev E Stat Nonlin Soft Matter Phys, volume 76, 2007. [bibtex] [pdf]
[44] P. Bursac, B. Fabry, X. Trepat, G. Lenormand, J. P. Butler, N. Wang, J. J. Fredberg, S. S. An
Cytoskeleton dynamics: Fluctuations within the network
In Biochem Biophys Res Commun, volume 355, 2007. [bibtex] [pdf]
[43] C. Y. Seow, S. S. An, T. R. Bai, J. H. T. Bates, J. L. Black, R. H. Brown, V. Brusasco, P. Chitano, L. Deng, M. Dowell, D. H. Eidelmann, B. Fabry, N. J. Fairbank, L. E. Ford, J. J. Fredberg, W. T. Gerthoffer, S. H. Gilbert, R. Gosens, S. J. Gunst, A. J. Halayko, R. H. Ingram, C. G. Irvin, A. L. James, L. J. Janssen, G. G. King, D. A. Knight, A. M. Lauzon, O. J. Lakser, M. S. Ludwig, K. R. Lutchen, G. N. Maksym, J. G. Martin, T. Mauad, B. E. McParland, S. M. Mijailovich, H. W. Mitchell, R. W. Mitchell, W. Mitzner, T. M. Murphy, P. D. Paré, R. Pellegrino, M. J. Sanderson, R. R. Schellenberg, P. S. P. Silveira, P. G. Smith, J. Solway, N. L. Stephens, P. J. Sterk, A. G. Stewart, D. D. Tang, R. S. Tepper, T. Tran, L. Wang
Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
In Eur Respir J, volume 29, 2007. [bibtex] [pdf]
[42] C. Metzner, C. Raupach, D. Paranhos Zitterbart, B. Fabry
Simple model of cytoskeletal fluctuations
In Phys Rev E, volume 76, 2007. [bibtex] [pdf]
[41] B. Fabry, J. J. Fredberg
Mechanotransduction, asthma, and airway smooth muscle
In Drug Discovery Today, volume 4, 2007. [bibtex] [pdf]
[40] P. Kollmannsberger, B. Fabry
High-Force Magnetic Tweezers with Force Feedback for Biological Applications
In Rev Sci Instrum, volume 78, 2007. [bibtex] [pdf]
[39] M. N. Oliver, B. Fabry, A. Marinkovic, S. M. Mijailovich, J. P. Butler, J. J. Fredberg
Airway Hyperresponsiveness, Remodeling, and Smooth Muscle Mass: Right Answer, Wrong Reason?
In Am J Respir Cell Mol Biol, volume 37, 2007. [bibtex] [pdf]
2006
[38] S. S. An, B. Fabry, X. Trepat, N. Wang, J. J. Fredberg
Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness?
In Am J Respir Cell Mol Biol, volume 35, 2006. [bibtex] [pdf]
[37] J. J. Fredberg, B. Fabry
The cytoskeleton as a soft glassy material. In: Cytoskeletal Mechanics: Models and Measurements.
Cambridge University Press, 2006. [bibtex] [pdf]
2005
[36] R. E. Laudadio, E. J. Millet, B. Fabry, S. S. An, J. P. Butler, J. J. Fredberg
Rat airway smooth muscle cell during actin modulation: rheology and glassy dynamics
In Am J Physiol Cell Physiol, volume 289, 2005. [bibtex] [pdf]
[35] P. Bursac, G. Lenormand, B. Fabry, M. Oliver, D. A. Weitz, V. Viasnoff, J. P. Butler, J. J. Fredberg
Cytoskeletal remodelling and slow dynamics in the living cell
In Nat Mater, volume 4, 2005. [bibtex] [pdf]
2004
[34] T. R. Bai, J. H. Bates, V. Brusasco, B. Camoretti-Mercado, P. Chitano, L. H. Deng, M. Dowell, B. Fabry, L. E. Ford, J. J. Fredberg, W. T. Gerthoffer, S. H. Gilbert, S. J. Gunst, C. M. Hai, A. J. Halayko, S. J. Hirst, A. L. James, L. J. Janssen, K. A. Jones, G. G. King, O. J. Lakser, R. K. Lambert, A. M. Lauzon, K. R. Lutchen, G. N. Maksym, R. A. Meiss, S. M. Mijailovich, H. W. Mitchell, R. W. Mitchell, W. Mitzner, T. M. Murphy, P. D. Pare, R. R. Schellenberg, C. Y. Seow, G. C. Sieck, P. G. Smith, A. V. Smolensky, J. Solway, N. L. Stephens, A. G. Stewart, D. D. Tang, L. Wang
On the terminology for describing the length-force relationship and its changes in airway smooth muscle
In J Appl Physiol, volume 97, 2004. [bibtex] [pdf]
[33] G. Lenormand, E. Millet, B. Fabry, J. P. Butler, J. J. Fredberg
Linearity and time-scale invariance of the creep function in living cells.
In J Royal Soc Interface, volume 1, 2004. [bibtex] [pdf]
[32] D. Stamenovic, B. Suki, B. Fabry, N. Wang, J. J. Fredberg
Rheology of airway smooth muscle cells is associated with cytoskeletal contractile stress
In J Appl Physiol, volume 96, 2004. [bibtex] [pdf]
[31] L. Deng, N. J. Fairbank, B. Fabry, P. G. Smith, G. N. Maksym
Localized mechanical stress induces time-dependent actin cytoskeletal remodeling and stiffening in cultured airway smooth muscle cells
In Am J Physiol Cell Physiol, volume 287, 2004. [bibtex] [pdf]
[30] M. Puig-de-Morales, E. Millet, B. Fabry, D. Navajas, N. Wang, J. P. Butler, J. J. Fredberg
Cytoskeletal mechanics in adherent human airway smooth muscle cells: probe specificity and scaling of protein-protein dynamics
In Am J Physiol Cell Physiol, volume 287, 2004. [bibtex] [pdf]
[29] S. S. An, B. Fabry, M. Mellema, P. Bursac, W. T. Gerthoffer, U. S. Kayyali, M. Gaestel, S. S. Shore, J. J. Fredberg
Role of Heat Shock Protein 27 in Cytoskeletal Remodeling of the Airway Smooth Muscle Cell
In J Appl Physiol, volume 96, 2004. [bibtex] [pdf]
2003
[28] J. Alcaraz, L. Buscemi, M. Grabulosa, X. Trepat, B. Fabry, R. Farre, D. Navajas
Microrheology of human lung epithelial cells measured by atomic force microscopy
In Biophys J, volume 84, 2003. [bibtex] [pdf]
[27] B. Fabry, G. N. Maksym, J. P. Butler, M. Glogauer, D. Navajas, A. N. Taback, E. J. Millet, J. J. Fredberg
Time scale and other invariants of integrative mechanical behavior in living cells
In Phys. Rev. E, volume 68, 2003. [bibtex] [pdf]
[26] X. Trepat, M. Grabulosa, L. Buscemi, F. Rico, B. Fabry, J.J. Fredberg, R. Farré
Oscillatory magnetic tweezers based on ferromagnetic beads and simple coaxial coils
In Rev Sci Instrum, volume 74, 2003. [bibtex] [pdf]
[25] V. D. Djordjevic, J. Jaric, B. Fabry, J. J. Fredberg, D. Stamenovic
Fractional derivatives embody essential features of cell rheological behavior
In Ann Biomed Eng, volume 31, 2003. [bibtex] [pdf]
[24] S. Hu, J. Chen, B. Fabry, Y. Numaguchi, A. Gouldstone, D. E. Ingber, J. J. Fredberg, J. P. Butler, N. Wang
Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells
In Am J Physiol Cell Physiol, volume 285, 2003. [bibtex] [pdf]
[23] B. Fabry, J. J. Fredberg
Remodeling of the airway smooth muscle cell: are we built of glass?
In Respir Physiol Neurobiol, volume 137, 2003. [bibtex] [pdf]
2002
[22] S. M. Mijailovich, M. Kojic, M. Zivkovic, B. Fabry, J. J. Fredberg
A finite element model of cell deformation during magnetic bead twisting
In J Appl Physiol, volume 93, 2002. [bibtex] [pdf]
[21] J. P. Butler, I. M. Tolic-Norrelykke, B. Fabry, J. J. Fredberg
Traction fields, moments, and strain energy that cells exert on their surroundings
In Am J Physiol Cell Physiol, volume 282, 2002. [bibtex] [pdf]
[20] J. Latourelle, B. Fabry, J. J. Fredberg
Dynamic equilibration of airway smooth muscle contraction during physiological loading
In J Appl Physiol, volume 92, 2002. [bibtex] [pdf]
2001
[19] B. Fabry, G. N. Maksym, J. P. Butler, M. Glogauer, D. Navajas, J. J. Fredberg
Scaling the microrheology of living cells
In Phys Rev Lett, volume 87, 2001. [bibtex] [pdf]
[18] J. Chen, B. Fabry, E. L. Schiffrin, N. Wang
Twisting integrin receptors increases endothelin-1 gene expression in endothelial cells
In Am J Physiol Cell Physiol, volume 280, 2001. [bibtex] [pdf]
[17] B. Fabry, G. N. Maksym, S. A. Shore, P. E. Moore, R. A. Jr. Panettieri, J. P. Butler, J. J. Fredberg
Time course and heterogeneity of contractile responses in cultured human airway smooth muscle cells
In J Appl Physiol, volume 91, 2001. [bibtex] [pdf]
2000
[16] F. J. Alenghat, B. Fabry, K. Y. Tsai, W. H. Goldmann, D. E. Ingber
Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer
In Biochem Biophys Res Commun, volume 277, 2000. [bibtex] [pdf]
[15] C. J. Meyer, F. J. Alenghat, P. Rim, J. H. Fong, B. Fabry, D. E. Ingber
Mechanical control of cyclic AMP signalling and gene transcription through integrins
In Nat Cell Biol, volume 2, 2000. [bibtex] [pdf]
[14] G. N. Maksym, B. Fabry, J. P. Butler, D. Navajas, D. J. Tschumperlin, J. D. Laporte, J. J. Fredberg
Mechanical properties of cultured human airway smooth muscle cells from 0.05 to 0.4 Hz
In J Appl Physiol, volume 89, 2000. [bibtex] [pdf]
1999
[13] C. Haberthür, B. Fabry, R. Stocker, R. Ritz, J. Guttmann
Additional inspiratory work of breathing imposed by tracheostomy tubes and non-ideal ventilator properties in critically ill patients
In Intensive Care Med, volume 25, 1999. [bibtex] [pdf]
[12] L. Eberhard, C. Haberthur, B. Fabry, J. Guttmann
Dynamic delay time compensation for sampling capillaries used in respiratory mass spectrometry
In Technol Health Care, volume 7, 1999. [bibtex] [pdf]
[11] J. D. Laporte, P. E. Moore, J. H. Abraham, G. N. Maksym, B. Fabry, R. A. Jr. Panettieri, S. A. Shore
Role of ERK MAP kinases in responses of cultured human airway smooth muscle cells to IL-1beta
In Am J Physiol, volume 277, 1999. [bibtex] [pdf]
[10] B. Fabry, G.N. Maksym, R.D. Hubmayr, J.P. Butler, J.J. Fredberg
Implications of heterogeneous bead behavior on cell mechanical properties measured with magnetic twisting cytometry
In J Magnetism Magnetic Materials, volume 194, 1999. [bibtex] [pdf]
1998
[9] C. Haberthür, B. Fabry, D. Zappe, J. Guttmann
Effects of mechanical unloading/loading on respiratory loop gain and periodic breathing in man
In Respir Physiol, volume 112, 1998. [bibtex] [pdf]
1997
[8] B. Fabry, C. Haberthur, D. Zappe, J. Guttmann, R. Kuhlen, R. Stocker
Breathing pattern and additional work of breathing in spontaneously breathing patients with different ventilatory demands during inspiratory pressure support and automatic tube compensation
In Intensive Care Med, volume 23, 1997. [bibtex] [pdf]
[7] M. Lichtwarck-Aschoff, J. Guttmann, L. Eberhard, B. Fabry, J. Birle, M. Adolph
Delayed derecruitment after removal of PEEP in patients with acute lung injury
In Acta Anaesthesiol Scand, volume 41, 1997. [bibtex] [pdf]
[6] R. Stocker, B. Fabry, L. Eberhard, C. Haberthur
Support of spontaneous breathing in the intubated patient: automatic tube compensation (ATC) and proportional assist ventilation (PAV)
In Acta Anaesthesiol Scand Suppl, volume 111, 1997. [bibtex] [pdf]
[5] J. Guttmann, H. Bernhard, G. Mols, A. Benzing, P. Hofmann, C. Haberthur, D. Zappe, B. Fabry, K. Geiger
Respiratory comfort of automatic tube compensation and inspiratory pressure support in conscious humans
In Intensive Care Med, volume 23, 1997. [bibtex] [pdf]
1996
[4] R. Stocker, B. Fabry, S. Stein, D. Zappe, O. Trentz, C. Haberthur
[Added work of breathing, respiratory pattern and determination of ventilator weaning readiness in inspiratory pressure support and and automatic tube compensation]
In Unfallchirurg, volume 99, 1996. [bibtex] [pdf]
1995
[3] J. Guttmann, L. Eberhard, B. Fabry, W. Bertschmann, J. Zeravik, M. Adolph, J. Eckart, G. Wolff
Time constant/volume relationship of passive expiration in mechanically ventilated ARDS patients
In Eur Respir J, volume 8, 1995. [bibtex] [pdf]
[2] B. Fabry, J. Guttmann, L. Eberhard, T. Bauer, C. Haberthur, G. Wolff
An analysis of desynchronization between the spontaneously breathing patient and ventilator during inspiratory pressure support
In Chest, volume 107, 1995. [bibtex] [pdf]
1993
[1] J. Guttmann, L. Eberhard, B. Fabry, W. Bertschmann, G. Wolff
Continuous calculation of intratracheal pressure in tracheally intubated patients
In Anesthesiology, volume 79, 1993. [bibtex] [pdf]