Mutated lamin A modulates stiffness in muscle cells
Biochem Biophys Res Commun (2020)
Projects
Pore size distributions in collagen networks (2011)
-Geometrical characterization of artificial extracellular matrices consisting of reconstituted collagen I
-Influence of collagen concentration and crosslinkers on pore size distribution
Thermal Noise Imaging: observing the topology of collagen networks (2012)
-Cooperation with Prof. E.-L. Florin, University of Texas at Austin
-Adaptation of TNI for investigations on 3D, wet samples, e.g. collagen networks
Collective cell migration (2012-2013)
-Cooperation with PD Pamela Strissel, PhD at University Clinics, Erlangen
-Correlation of macroscopic growth of artificial tumor cell colonies with collective migration of cells
Cell rheology measurements with microfluidic devices (2013-2017)
-Cooperation with Prof. Graeme Whyte, Heriot-Watt University, Edinburgh
-Practical and theoretical development of a microfluidic measurement tool to investigate cell stiffness and fluidity in a high-throughput, quantitative way
-Biological application of the setup in many national and international collaborations
Curriculum Vitae
FAU Erlangen-Nuremberg:
-PhD in biophysics, (2013-2017)
-Physics (M.Sc.) , 2013
-Physics (B.Sc.) , 2011
Dr.-Johanna-Decker-Gymnasium, Amberg:
Abitur, (2008)
Conferences
Annual meeting of the German biophysical society, Erlangen, Germany,
2016/10/04-2016/10/06:
Janina R. Lange, Claus Metzner, Sebastian Richter, Werner Schneider, Monika Spermann, Thorsten Kolb, Graeme Whyte, Ben Fabry
Unbiased high precision cell mechanical measurements with microconstrictions
Physics of Cancer, (7th Annual Meeting), Leipzig, Germany, 2016/10/04-2016/10/06:
Janina R. Lange, Claus Metzner, Sebastian Richter, Werner Schneider, Monika Spermann, Thorsten Kolb, Graeme Whyte, Ben Fabry
Unbiased high precision cell mechanical measurements with microconstrictions
Biophysical Society 60th Meeting, Los Angeles, USA, 2016/02/27-2016/03/02:
Janina R. Lange, Julian Steinwachs, Claus Metzner, Graeme Whyte, Ben Fabry
Cell mechanical properties measured with micron-scale constrictions: influence of pressure, strain, and culture conditions
6th European Cell Mechanics Meeting, Barcelona, Spain, 2015/05/13-2015/05/15:
Janina R. Lange, Julian Steinwachs, Thorsten Kolb, Lena A. Lautscham, Irina Harder, Graeme Whyte, Ben Fabry
Microconstriction arrays for high throughput quantitative measurements of cell mechanical properties
Physics of Cancer, (5rd Annual Meeting), Leipzig, Germany, 2014/10/02-2014/10/05:
Janina R. Lange, Thorsten Kolb, Jonas Hallmen, Graeme Whyte, Ben Fabry
Cell deformability during passage through micron-scale constrictions
Biophysical Society 58th Meeting, San Francisco, USA, 2014/02/15-2014/02/19:
Janina R. Lange, Michael Haug, Thorsten Kolb, Sahradha Albert, Graeme Whyte, Ben Fabry
Nuclear deformability is critically dependent on Lamin A/B
5th European Cell Mechanics Meeting, Obergurgel, Austria, 2013/09/28-2013/10/02:
Janina R. Lange, Claus Metzner, Patrick Krauss, Pamela Strissel, Ben Fabry
Collective Migration during the Growth of mesenchymal and epithelial cell colonies
Annual Meeting of the German Physical Society (DPG), Regensburg, Germany, 2013/03/11-2013/03/15
Janina R. Lange, Claus Metzner, Patrick Krauss, Pamela Strissel, Ben Fabry
The role of collective cell migration during tumor growth
Patrick Krauss, Claus Metzner, Janina Lange, Ben Fabry
Physics of Emergent Behavior (IOP), Brighton, GB, 2013/06/23-2013/06/26:
Janina R. Lange, Claus Metzner, Patrick Krauss, Pamela Strissel, Ben Fabry
Collective migration during the growth of epithelial and mesenchymal cell colonies, Poster Prize
Patrick Krauss, Claus Metzner, Janina R. Lange, Ben Fabry
Emergence of cell colony dynamics from proliferating particles with Lennard-Jones like interactions
Biophysical Society 57th Meeting, Philadelphia, USA, 2013/02/02-2013/02/06
Tobias F. Bartsch, Martin D. Kochanczyk, Janina R. Lange, Ernst-Ludwig Florin
Three-dimensional thermal noise imaging of collagen networks
Physics of Cancer (3rd Annual Meeting), Leipzig, Germany, 2012/11/01-2012/11/03
Janina R. Lange, Claus Metzner, Julian Steinwachs, Pamela Strissel, Ben Fabry
3D topology of tumor cell colonies on a 2D substrate
Publications
2020
alphavbeta3 integrin expression increases elasticity in human melanoma cells
Biochem Biophys Res Commun (2020)
2018
Pressure-driven collective growth mechanism of planar cell colonies
Journal of Physics D-Applied Physics (2018)
2017
Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions
Biophys J (2017)
2016
Influence of alphavbeta3 integrin on the mechanical properties and the morphology of M21 and K562 cells
Biochem Biophys Res Commun (2016)
Cell Mechanical Properties Measured with Micron-Scale Constrictions: Influence of Pressure, Strain and Culture Conditions
(2016)
PDF not available DOI / publisher
2015
Microconstriction Arrays for High-Throughput Quantitative Measurements of Cell Mechanical Properties
Biophys J (2015)
Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness
Biophys J (2015)
2014
Nuclear deformability is critically dependent on lamin A/B
(2014)
PDF not available DOI / publisher
2013
Estimating the 3D pore size distribution of biopolymer networks from directionally biased data
Biophys J (2013)
Influence of focal adhesion kinase on the mechanical behavior of cell populations
Biochem Biophys Res Commun (2013)
Cell and tissue mechanics in cell migration
Exp Cell Res (2013)
Differences in mesenchymal and epithelial cell colony growth
(2013)
PDF not available
2012
Parameter-Free Binarization and Skeletonization of Fiber Networks from Confocal Image Stacks
PLoS ONE (2012)
2011
Characterization of collagen gel pore sizes from confocal reflection images
(2011)
PDF not available